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Drug Delivery and Translational Research

, Volume 9, Issue 1, pp 204–214 | Cite as

Dual rotation centrifugal electrospinning: a novel approach to engineer multi-directional and layered fiber composite matrices

  • Li Wang
  • Baolin Wang
  • Zeeshan Ahmad
  • Jing-Song Li
  • Ming-Wei ChangEmail author
Original Article
  • 48 Downloads

Abstract

In this study, a dual rotation centrifugal electrospinning system (DRCES) is designed, developed, and used to prepare medicated fabrics. Through simultaneous rotation of both spinneret and collector, multi-directional blended fiber matrices (PVP and TPU) were deposited directly on the rotating collector. To detail the process, key stages of the centrifugal electrospinning process are elaborated, and the influence of gas infusion and collector rotation speed on resulting fiber morphologies was explored. Multi-directional fibrous structures show in vitro biocompatibility (fibroblast). Regulation of drug release rate was achieved using polymer composition and filament alignment. This study demonstrates a rapid fabrication method (~ 50 g/h) to engineer layered fibrous structures using DRCES, which provides a foundation for preparing complex drug matrices (single and multi-directional) for tailored active component release.

Keywords

Centrifugal electrospinning Dual rotation Layers Composite fiber Multi-directional 

Notes

Funding information

This work was financially supported by the National Nature Science Foundation of China (No. 81771960), the Fundamental Research Funds for the Central Universities (2017QNA5017), and Key Technologies R&D Program of Zhejiang Province (2015C02035).

Compliance with ethical standards

Competing interests

The authors declare that they have no conflicts of interest.

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Copyright information

© Controlled Release Society 2018

Authors and Affiliations

  1. 1.Key Laboratory for Biomedical Engineering of Education Ministry of ChinaZhejiang UniversityHangzhouPeople’s Republic of China
  2. 2.Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, College of Biomedical Engineering & Instrument ScienceZhejiang UniversityHangzhouPeople’s Republic of China
  3. 3.The Leicester School of PharmacyDe Montfort UniversityLeicesterUK

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