Diabetology International

, Volume 10, Issue 1, pp 77–82 | Cite as

Effect of deglutition aids on the inhibitory effect of orally disintegrating tablets of voglibose on the postprandial elevation of blood glucose levels: a case investigating the interaction between xanthan gum and voglibose

  • Takashi TomitaEmail author
  • Hidekazu Goto
  • Kenji Sumiya
  • Tadashi Yoshida
  • Kenzo Kudo
  • Yukinao Kohda
Short Communication


In this study, we first performed a disintegration test of the voglibose orally disintegrating (V-OD) tablet immersed in jelly-wafer (JW, V-ODims/jw) for 10 min and compared it with the disintegration time of V-OD that was not immersed in JW. We then orally administered the V-ODims/jw tablet to 7 healthy adults and compared the shift in blood glucose levels (BGLs), after loading with a sucrose solution (Suc-sol, 100 g/150 mL), with that after administration of the non-immersed V-OD tablet. The disintegration time of V-ODims/jw tablet was shorter than that of V-OD. When administered to healthy adults, the BGL after loading with Suc-sol was higher with V-ODims/jw tablet administration than with V-OD tablet. We predict that the expression of the efficacy of voglibose is reduced as a result of the interaction between voglibose and the polysaccharide, xanthan gum (XG), since it is a common additive in JW. This study shows that deglutition aids with additives that do not affect pharmacokinetics must be carefully selected for administering along with pharmaceuticals, because of a suggested possibility that the interaction between these pharmaceuticals and the additives in the deglutition aids weaken the drug efficacy. A more careful selection of deglutition aids from the wide selection of medication is especially important when administered to patients who use these deglutition aids often, such as elderly individuals or individuals with a deglutition disorder.


Xanthan gum Jelly-wafer Voglibose Orally disintegrating tablet Blood glucose elevation 



Area under the incremental concentration–time curve


Blood glucose levels


Food thickener


The Japanese Pharmacopoeia, 17th edition




Sucrose solution


Voglibose orally disintegrating tablet


Voglibose orally disintegrating tablet immersed in food thickener


Voglibose orally disintegrating tablet immersed in jelly-wafer


Xanthan gum


Compliance with ethical standards

Conflict of interest

None of the authors have any conflicts of interest associated with this study.

Ethical standards

This study was carried out in accordance with the Declaration of Helsinki of 1964 and later versions and approved by the ethics committee of Hospital BANDO (approval number: not applicable, approval date: 8 March 2017).

Informed consent

The healthy Japanese adult males gave their written informed consent to participate in this study and its results to be published.


  1. 1.
    Deto A, Yamagata Y, Kayashita J. Effects of temperature on the physical properties of various commercial thickening agents for dysphagia. Bull Fac Hum Cult Sci Pref Univ Hiroshima. 2007;2:39–47.Google Scholar
  2. 2.
    Nakamura M, Yoshida S, Nishioka Y, Hayashi S, Suzuki YA. Categorization of commercial thickeners on the basis of their effects on the physical properties of foods. Jpn J Nutr Diet. 2012;70:59–70.CrossRefGoogle Scholar
  3. 3.
    Yamaguchi H, Ochiai A, Takiya H. Abstracts of papers, the 24th annual meeting of Japanese society of pharmaceutical health care and sciences, Nagoya; 2014. p. 371.Google Scholar
  4. 4.
    Tomita T, Goto H, Yoshimura Y, Tsubouchi Y, Nakanishi R, Kojima C, Yoneshima M, Yoshida T, Tanaka K, Sumiya K, Kohda Y. Effect of food thickener on disintegration and dissolution of magnesium oxide tablets. Yakugaku Zasshi. 2015;135:835–40.CrossRefGoogle Scholar
  5. 5.
    Tomita T, Goto H, Sumiya K, Nakanishi R, Kojima C, Yoneshima M, Yoshida T, Tanaka K, Kohda Y. Effect of food thickener on disintegration of donepezil hydrochloride orally disintegrating tablets. Igaku No Ayumi. 2015;253:677–8.Google Scholar
  6. 6.
    Goto H, Tomita T, Sumiya K, Nakanishi R, Kojima C, Yoneshima M, Yoshida T, Tanaka K, Kohda Y. Effect of food thickener on tablet disintegration of rapid-disintegration over-the-counter drugs. J Community Pharm Pharm Sci. 2016;8:88–91.Google Scholar
  7. 7.
    Tomita T, Goto H, Sumiya K, Yoshida T, Tanaka K, Kohda Y. The effect of food thickener on the inhibitory effect of voglibose oral disintegrating tablet on post-prandial elevation of blood sugar levels. Yakugaku Zasshi. 2016;136:1171–6.CrossRefGoogle Scholar
  8. 8.
    Package insert of BASEN®OD Tablets 0.2&0.3, Takeda Pharmaceutical Co., Ltd. 2014.Google Scholar
  9. 9.
    Guidance for industry: orally disintegrating tablets. Food and Drug Administration, Center for Drug Evaluation and Research. 2008.Google Scholar
  10. 10.
    Tone E, Hashimoto Y, Nakamura E, Kamita Y, Kido W, Tashiro M, Matsuura T. Interaction between soluble dietary fiber and acetaminophen. Jpn J Food Chem Saf. 2013;20:141–6.Google Scholar
  11. 11.
    Hashimoto Y, Nakamura E, Matsuura T. Study of drug interaction with xanthan gum using rat portal vein catheterization. Jpn J Food Chem Saf. 2016;23:126–32.Google Scholar
  12. 12.
    Hirose T, Kawamori R, Mita T, Watada H, Fujitani Y. Glucose monitoring after fruit peeling: pseudohyperglycemia when neglecting hand washing before fingertip blood sampling. Diabetes Care. 2011;34:596–7.CrossRefGoogle Scholar
  13. 13.
    Atkin SH, Dasmahapatra A, Jaker MA, Chorost MI, Reddy S. Fingerstick glucose determination in shock. Ann Int Med. 1991;114:1020–4.CrossRefGoogle Scholar
  14. 14.
    Sandler M, Low-Beer T. Misleading capillary glucose measurements. Pract Diabetes. 1990;7:210.CrossRefGoogle Scholar
  15. 15.
    Wickham NWR, Achar KN, Cove DH. Unreliability of capillary blood glucose in peripheral vascular disease. Pract Diabetes. 1986;3:100.CrossRefGoogle Scholar
  16. 16.
    Jungheim K, Koschinsky T. Glucose monitoring at the arm: risky delays of hypoglycemia and hyperglycemia detection. Diabetes Care. 2002;25:956–60.CrossRefGoogle Scholar

Copyright information

© The Japan Diabetes Society 2018

Authors and Affiliations

  1. 1.Department of Clinical Pharmaceutics and Pharmacy Practice, School of PharmacyIwate Medical UniversityShiwagunJapan
  2. 2.Department of PharmacyHospital BandoBandoJapan
  3. 3.Faculty of PharmacyIwaki Meisei UniversityIwakiJapan
  4. 4.Department of Internal MedicineHospital BandoBandoJapan
  5. 5.Faculty of Health SciencesTsukuba International UniversityTsuchiuraJapan

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