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Enhanced bioavailability of orally administered flurbiprofen by combined use of hydroxypropyl-cyclodextrin and poly(alkyl-cyanoacrylate) nanoparticles

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Abstract

Flurbiprofen was formulated into nanoparticle suspension to improve its oral bioavailability. Hydroxypropyl-β-cyclodextrin inclusion–flurbiprofen complex (HP-β-CD–FP) was prepared, then incorporating this complex into poly(alkyl-cyanoacrylate) (PACA) nanoparticles. HP-β-CD–FP–PACA nanoparticle was prepared by the emulsion solvent polymerization method. The zeta potential was −26.8 mV, the mean volume particle diameter was 134 nm, drug encapsulation efficiency was 53.3 ± 3.6 % and concentration was 1.5 mg/mL. The bioavailability of flurbiprofen from optimized nanoparticles was assessed in male Wistar rats at a dose of 15 mg/kg. As compared to the flurbiprofen suspension, 211.6 % relative bioavailability was observed for flurbiprofen nanoparticles. The reduced particle size and increased surface area may contribute to improve oral bioavailability of flurbiprofen.

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References

  • Boudad H, Legrand P, Lebas G, Cheron M, Duchêne D, Ponchel G (2001) Combined hydroxypropyl-cyclodextrin and poly(alkylcyanoacrylate) nanoparticles intended for oral administration of saquinavir. Int J Pharm 218:113–124

    Article  CAS  PubMed  Google Scholar 

  • Jain SK, Chourasia MK, Masuriha R, Soni V, Jain A, Jain NK, Gupta Y (2005) Solid lipid nanoparticles bearing flurbiprofen for transdermal delivery. Drug Deliv 12:207–215

    Article  CAS  PubMed  Google Scholar 

  • Kang JH, Oh DH, Oh YK, Yong CS, Choi HG (2012) Effects of solid carriers on the crystalline properties, dissolution and bioavailability of flurbiprofen in solid self-nanoemulsifying drug delivery system (solid SNEDDS). Eur J Pharm Biopharm 80:289–297

    Article  CAS  PubMed  Google Scholar 

  • Kwon SY, Rho SJ, Lee WS, Yang HJ, Hah JM, Choi HG, Kim YR, Yong CS (2011) Enhanced solubility and bioavailability of flurbiprofen by cycloamylose. Arch Pharm Res 34:391–397

    Article  PubMed  Google Scholar 

  • Li DX, Han MJ, Balakrishnan P, Yan YD, Oh DH, Joe JH, Seo Y, Kim JO, Park SM, Yong CS, Choi HG (2010) Enhanced oral bioavailability of flurbiprofen by combined use of micelle solution and inclusion compound. Arch Pharm Res 33:95–101

    Article  CAS  PubMed  Google Scholar 

  • Mulik R, Mahadik K, Paradkar A (2009) Development of curcuminoids loaded poly(butyl)cyanoacrylate nanoparticles: physicochemical characterization and stability study. Eur J Pharm Sci 37:395–404

    Article  CAS  PubMed  Google Scholar 

  • Pignatello R, Bucolo C, Spedalieri G, Maltese A, Puglisi G (2002) Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application. Biomaterials 23:3247–3255

    Article  CAS  PubMed  Google Scholar 

  • Sajeesh S, Chandra P, Sharma S (2006) Cyclodextrin–insulin complex encapsulated polymethacrylic acid based nanoparticles for oral insulin delivery. Int J Pharm 325:147–154

    Article  CAS  PubMed  Google Scholar 

  • Vauthier C, Labarre D, Ponchel G (2007) Design aspects of poly(alkylcyanoacrylate) nanoparticles for drug delivery. J Drug Target 15:641–663

    Article  CAS  PubMed  Google Scholar 

  • Vega E, Egea MA, Valls O, Espina M, García ML (2006) Flurbiprofen loaded biodegradable nanoparticles for ophthalmic administration. J Pharm Sci 95:2393–2405

    Article  CAS  PubMed  Google Scholar 

  • Vega E, Egea MA, Calpena AC, Espina M, García ML (2012) Role of hydroxypropyl-β-cyclodextrin on freeze-dried and gamma-irradiated PLGA and PLGA-PEG diblock copolymer nanospheres for ophthalmic flurbiprofen delivery. Int J Nanomedicine 7:1357–1371

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

The authors are very grateful to Mr. Haibo Zhou for assistance in the experimental work.

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Authors and Affiliations

  1. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

    Xiaoyun Zhao

  2. School of Chinese Traditional Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China

    Wei Li & Xiangrong Zhang

  3. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China

    Qiuhua Luo

Authors
  1. Xiaoyun Zhao
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  2. Wei Li
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  3. Qiuhua Luo
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  4. Xiangrong Zhang
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Correspondence to Xiangrong Zhang.

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Zhao, X., Li, W., Luo, Q. et al. Enhanced bioavailability of orally administered flurbiprofen by combined use of hydroxypropyl-cyclodextrin and poly(alkyl-cyanoacrylate) nanoparticles. Eur J Drug Metab Pharmacokinet 39, 61–67 (2014). https://doi.org/10.1007/s13318-013-0138-9

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  • DOI: https://doi.org/10.1007/s13318-013-0138-9

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