Indian Pediatrics

, Volume 56, Issue 11, pp 911–912 | Cite as

Do Inhaled Corticosteroids Alter Nasopharyngeal Flora in Children with Asthma?

  • Kana Ram Jat
  • Rakesh LodhaEmail author


Funding: None; Competing interests: None stated.


  1. 1.
    Zaidi SR, Blakey JD. Why are people with asthma susceptible to pneumonia? A review of factors related to upper airway bacteria. Respirology. 2019;24:423–30.CrossRefGoogle Scholar
  2. 2.
    van der Sluijs KF, van Elden LJR, Nijhuis M, Schuurman R, Florquin S, Shimizu T, et al. Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia. Am J Physiol Lung Cell Mol Physiol. 2006;290:L194–9.CrossRefGoogle Scholar
  3. 3.
    Wolter N, Tempia S, Cohen C, Madhi SA, Venter M, Moyes J, et al. High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia. J Infect Dis. 2014;210:1649–57.CrossRefGoogle Scholar
  4. 4.
    Nirmal G, Awasthi S, Gupta S, Aggarwal J. Effect of different doses of inhaled corticosteroids on the isolation of nasopharyngeal flora in children with asthma. Indian Pediatr. 2019;56:913–6.PubMedGoogle Scholar
  5. 5.
    Esposito S, Terranova L, Patria MF, Marseglia GL, Miraglia del Giudice M, Bodini A, et al. Streptococcus pneumoniae colonisation in children and adolescents with asthma: impact of the heptavalent pneumococcal conjugate vaccine and evaluation of potential effect of thirteen-valent pneumococcal conjugate vaccine. BMC Infect Dis. 2016;16:12.CrossRefGoogle Scholar
  6. 6.
    Cardozo DM, Nascimento-Carvalho CM, Andrade A-LSS, Silvany-Neto AM, Daltro CHC, Brandão M-AS, et al. Prevalence and risk factors for nasopharyngeal carriage of Streptococcus pneumoniae among adolescents. J Med Microbiol. 2008;57:185–9.CrossRefGoogle Scholar
  7. 7.
    Zhang L, Prietsch SOM, Mendes AP, Von Groll A, Rocha GP, Carrion L, et al. Inhaled corticosteroids increase the risk of oropharyngeal colonization by Streptococcus pneumoniae in children with asthma. Respirology. 2013;18:272–7.CrossRefGoogle Scholar
  8. 8.
    Jounio U, Juvonen R, Bloigu A, Silvennoinen-Kassinen S, Kaijalainen T, Kauma H, et al. Pneumococcal carriage is more common in asthmatic than in non-asthmatic young men. Clin Respir J. 2010;4:222–9.CrossRefGoogle Scholar
  9. 9.
    Lin H, Sun Y, Lin R, Xu J, Li N. [Influence of inhaled corticosteroids on distribution of throat flora in children with bronchial asthma]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010;45:656–9.PubMedGoogle Scholar
  10. 10.
    Alsuwaidi AR, Alkalbani AM, Alblooshi A, George J, Albadi G, Kamal SM, et al. Nasopharyngeal isolates and their clinical impact on young children with asthma: a pilot study. J Asthma Allergy. 2018;11:233–43.CrossRefGoogle Scholar

Copyright information

© Indian Academy of Pediatrics 2019

Authors and Affiliations

  1. 1.Department of PediatricsAll India Institute of Medical SciencesNew DelhiIndia

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