Indian Pediatrics

, Volume 56, Issue 9, pp 735–740 | Cite as

Predictive Value of Vasoactive-inotropic Score for Mortality in Newborns Undergoing Cardiac Surgery

  • Dilek DilliEmail author
  • Hasan Akduman
  • Utku Arman Orun
  • Mehmet Tasar
  • Irfan Tasoglu
  • Seda Aydogan
  • Rumeysa Citli
  • Sercan Tak
Research Paper



Vasoactive-inotropic Score (VIS) was developed to quantify the amount of inotropic support provided in the postoperative period. We investigated the predictive value of (VIS) for mortality in neonates with congenital heart disease (CHD).

Study design

Prospective cohort.


119 newborns who underwent cardiac surgery.


Tertiary NICU-CHD center of Ankara from November 2016 to January 2019.


VIS values were calculated by a standard formula for the first 72 postoperative hours, and the maximum score was recorded.

Primary outcomes

Duration of mechanical ventilation, NICU length of stay, and mortality.


At surgery, the median (IQR) age was 15 d (9–31). The patients were divided into two groups according to mortality; Group 1 (Non-survivors) (n=36) and Group 2 (Survivors) (n=83). Higher VIS score was correlated to longer duration of mechanical ventilation (P=0.009, r=0.33), and was higher among patients who died (P=0.003). Area under the curve (AUC) was 0,83 (P<.001, CI: 95% 0.7–0.9) for VIS to identify mortality. At a cut-off value of 15.5, sensitivity and negative predictive values of VIS for mortality were 73.6% and 85.3%, respectively. The higher VIS (>15.5) was independently associated with increased odds for mortality (OR: 8.1, 95% CI: 1.8–35.7, P=0.005).


In newborns with CHD, a higher VIS within 72 hours after cardiac surgery is associated with increased duration of mechanical ventilation, and mortality. VIS may be useful for prediction of mortality at early postoperative period.


Congenital heart disease Outcome Repair Survival 


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Funding: None.


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Copyright information

© Indian Academy of Pediatrics 2019

Authors and Affiliations

  • Dilek Dilli
    • 1
    Email author
  • Hasan Akduman
    • 1
  • Utku Arman Orun
    • 2
  • Mehmet Tasar
    • 3
  • Irfan Tasoglu
    • 4
  • Seda Aydogan
    • 1
  • Rumeysa Citli
    • 1
  • Sercan Tak
    • 3
  1. 1.Department of NeonatologySami Ulus Maternity and Children Research and Training HospitalAnkaraTurkey
  2. 2.Department of Pediatric CardiologySami Ulus Maternity and Children Research and Training HospitalAnkaraTurkey
  3. 3.Department of Pediatric Cardiovascular SurgerySami Ulus Maternity and Children Research and Training HospitalAnkaraTurkey
  4. 4.Turkiye Yuksek Ihtisas Training and Research HospitalUniversity of Health SciencesAnkaraTurkey

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