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Indian Pediatrics

, Volume 56, Issue 10, pp 841–844 | Cite as

Comparison of Soybean-based Oil and MCT-olive-fish-soy Oil Intravenous Lipid Emulsions on Soluble Adhesion Markers in Preterm Neonates with Sepsis: A Randomized Controlled Trial

  • Mohammed Abdelkareem
  • Yahya WahbaEmail author
  • Basma Shouman
  • Abeer Mesbah
Research Paper
  • 5 Downloads

Abstract

Objectives

To compare the effects of two different intravenous lipid emulsions on soluble adhesion markers in preterm infants with sepsis.

Methods

This randomized controlled pilot trial was conducted from February 2016 to February 2017. 40 preterm infants with sepsis were enrolled and assigned to receive either Medium chain triglyceride-Olive-Fish-Soy lipid emulsion (MOFS-LE) or soybean oil-based lipid emulsion (S-LE). Outcomes of the study were changes in sICAM-1 and leukocyte integrin β2 levels, and growth after 7 days of intervention.

Results

Leukocyte integrin β2 was significantly higher in MOFS-LE group. No statistically significant differences were observed for sICAM-1, duration of mechanical ventilation and antibiotics treatment, and mortality rate.

Conclusions

Leukocyte integrin β2 was significantly higher in preterm septic neonates who received MOFS-LE.

Keywords

Parenteral nutrition Polyunsaturated fatty acids Soluble adhesion molecules 

Trial registration

ClinicalTrials.gov (NCT03275090) 

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Notes

Funding: None; Competing Interest: None stated.

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Copyright information

© Indian Academy of Pediatrics 2019

Authors and Affiliations

  • Mohammed Abdelkareem
    • 1
  • Yahya Wahba
    • 1
    Email author
  • Basma Shouman
    • 1
  • Abeer Mesbah
    • 2
  1. 1.Department of Pediatrics, Faculty of MedicineMansoura UniversityMansouraEgypt
  2. 2.Department of Clinical Pathology, Faculty of MedicineMansoura UniversityMansouraEgypt

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