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Indian Pediatrics

, Volume 56, Issue 10, pp 825–830 | Cite as

Predictors of Malnutrition in Children with Cystic Fibrosis

  • Nitin Dhochak
  • Kana Ram Jat
  • Jhuma Sankar
  • Rakesh Lodha
  • Sushil K. KabraEmail author
Research Paper
  • 7 Downloads

Abstract

Objective

To determine occurrence of malnutrition in children with cystic fibrosis and identify predictors of malnutrition at time of enrolment and after 2 years of follow up.

Design

Retrospective chart review.

Setting

Pediatric chest clinic at a tertiary-care center in northern India.

Patients

Cystic fibrosis patients enrolled between 2009–2015 with at least 3 years follow-up.

Procedure

Weight and height were noted at enrolment, and after 1 year and 2 years of follow-up. Clinical details, medications, and pulmonary exacerbations during second year were recorded.

Main outcome measure

Occurrence of malnutrition i.e. weight for age Z-score < −2.

Results

61 medical records were reviewed. Occurrence of malnutrition at baseline, and 1- and 2-year follow-up was 65.5%, 54.1% and 57.3%, respectively. Weight for age Z-score at enrolment significantly correlated with time to diagnosis from onset r=0.015, P=0.029). Weight for age Z-score at 2-year follow-up was significantly associated with steatorrhea (P=0.03), increased frequency of stools (P<0.01) and pulmonary exacerbation (P=0.03) during second year. Linear regression showed significant association between weight for age Z-score at 2 years with steatorrhea and pulmonary exacerbations [r=−10.795 (−1.527, −0.062)] and [r=−0.261 (−0.493, −0.028)]. Pulmonary exacerbations during second and third year had significant correlation with weight for age Z-score at the beginning of respective years (r = −0.219, P=0.015).

Conclusion

Occurrence of malnutrition is high in children with cystic fibrosis in this region, with uncontrolled fat malabsorption and recurrent respiratory infections being significant risk factors.

Keywords

Fat malabsorption Nutrition Pulmonary exacerbation 

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Notes

Funding: None; Competing interests: None stated.

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Copyright information

© Indian Academy of Pediatrics 2019

Authors and Affiliations

  • Nitin Dhochak
    • 1
  • Kana Ram Jat
    • 1
  • Jhuma Sankar
    • 1
  • Rakesh Lodha
    • 1
  • Sushil K. Kabra
    • 1
    Email author
  1. 1.Department of PediatricsAll India Institute of Medical SciencesNew DelhiIndia

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