Indian Pediatrics

, Volume 55, Issue 12, pp 1059–1061 | Cite as

Prediction of Transient or Permanent Congenital Hypothyroidism from Initial Thyroid Stimulating Hormone Levels

  • Maria Scavone
  • Elena Carboni
  • Ettore Stefanelli
  • Giusy Romano
  • Anna Vero
  • Laura Giancotti
  • Roberto Miniero
  • Valentina TalaricoEmail author
Research Paper



To identify factors that discriminate between transient and permanent congenital hypothyroidism.


Retrospective evaluation of 58 children with congenital hypothyroidism and eutopic thyroid gland. Gender, gestational age, birth weight, TSH and serum thyroxine levels at diagnosis and L-thyroxine dose at 12 and 24 months of age were analyzed.


Median (IQR) initial TSH levels were 73.3 (276.5) μIU/mL in permanent hypothyroidism and 24.24 (52.7) μU/mL in transient hypothyroidism (P =0.0132). The optimum cut-off value of initial TSH to predict transient hypothyroidism was 90 μIU/mL. Mean (SD) L-thyroxine doses at 24 months of age were 2.64 (0.98) μg/kg/day in permanent hypothyroidism and 1.91 (0.65) μg/kg/day in transient hypothyroidism. Requirement of Lthyroxine dose at 24 months of ≤0.94 μg/kg/day had the highest sensitivity (100%) to predict transient hypothyroidism.


L-thyroxine doses at 24 months can predict transient hypothyroidism in patients with eutopic thyroid gland earlier than at 36 months.


Cretinism Transient hypothyroidism Thyroid hormones Thyroxine 


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Copyright information

© Indian Academy of Pediatrics 2018

Authors and Affiliations

  • Maria Scavone
    • 1
  • Elena Carboni
    • 1
  • Ettore Stefanelli
    • 1
  • Giusy Romano
    • 1
  • Anna Vero
    • 2
  • Laura Giancotti
    • 1
  • Roberto Miniero
    • 1
  • Valentina Talarico
    • 3
    • 4
    Email author
  1. 1.Unit of PediatricsMagna Graecia University of CatanzaroCatanzaroItaly
  2. 2.Units of Laboratory MedicineCatanzaroItaly
  3. 3.Pediatrics, Pugliese- Ciaccio HospitalCatanzaroItaly
  4. 4.Unit of PediatricsPugliese-Ciaccio HospitalViale Pio XItaly

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