Fungal microbiome in colorectal cancer: a systematic review
Colorectal cancer (CRC) is the third cause of cancer-related death worldwide. It has been estimated that more than one million new cases occur every year. Several studies have investigated the role of host bacteria as agents protecting against or increasing the risk of CRC, but few have assessed the fungal microbiome in patients with CRC. Fungal dysbiosis has been studied in colorectal diseases (e.g. inflammatory bowel diseases), but few researches compared the fungal microbiome of CRC patients with those of controls. The current study represents a systematic review aimed at assessing the expression and diversity of fungi in patients with CRC and non-CRC individuals. Here, we discuss the fungal species that could be implied in CRC development and alterations that can be induced by the presence of CRC, and the potential implications for future research.
KeywordsColorectal cancer Treatment Diagnosis Biomarkers Fungal microbiome Fungi
The authors wish to thank the Royal Marsden Hospital Biomedical Research Council (BRC) for their support.
All authors have no source of funding.
Compliance with ethical standards
Conflict of interest
All authors have no conflict of interest.
Research involving human participants and/or animals
The authors did not perform any procedures on patients in this manuscript (review).
For this type of study, no informed consent was needed.
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