Updates in Surgery

, Volume 71, Issue 4, pp 625–630 | Cite as

Fungal microbiome in colorectal cancer: a systematic review

  • Arun Anandakumar
  • Gianluca PellinoEmail author
  • Paris Tekkis
  • Christos Kontovounisios
Review Article


Colorectal cancer (CRC) is the third cause of cancer-related death worldwide. It has been estimated that more than one million new cases occur every year. Several studies have investigated the role of host bacteria as agents protecting against or increasing the risk of CRC, but few have assessed the fungal microbiome in patients with CRC. Fungal dysbiosis has been studied in colorectal diseases (e.g. inflammatory bowel diseases), but few researches compared the fungal microbiome of CRC patients with those of controls. The current study represents a systematic review aimed at assessing the expression and diversity of fungi in patients with CRC and non-CRC individuals. Here, we discuss the fungal species that could be implied in CRC development and alterations that can be induced by the presence of CRC, and the potential implications for future research.


Colorectal cancer Treatment Diagnosis Biomarkers Fungal microbiome Fungi 



The authors wish to thank the Royal Marsden Hospital Biomedical Research Council (BRC) for their support.


All authors have no source of funding.

Compliance with ethical standards

Conflict of interest

All authors have no conflict of interest.

Research involving human participants and/or animals

The authors did not perform any procedures on patients in this manuscript (review).

Informed consent

For this type of study, no informed consent was needed.

Supplementary material

13304_2019_683_MOESM1_ESM.doc (64 kb)
Supplementary material 1 (DOC 64 kb)


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Copyright information

© Italian Society of Surgery (SIC) 2019

Authors and Affiliations

  1. 1.Department of Colorectal SurgeryChelsea and Westminster HospitalLondonUK
  2. 2.Department of Advanced Medical and Surgical SciencesUniversità degli Studi della Campania “Luigi Vanvitelli”NaplesItaly
  3. 3.Department of Colorectal SurgeryRoyal Marsden HospitalLondonUK
  4. 4.Department of Surgery and CancerImperial CollegeLondonUK

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