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A review and analysis of stereotactic body radiotherapy and radiosurgery of patients with cardiac implantable electronic devices

  • Hossein AslianEmail author
  • Tomas Kron
  • Francesco Longo
  • Roya Rad
  • Mara Severgnini
Review Paper
  • 36 Downloads

Abstract

The implementation of stereotactic body radiation therapy (SBRT) and stereotactic radiosurgery (SRS) has greatly increased due to its convenience and advantages from perspectives ranging from radiobiology to radio physics. Because SBRT/SRS delivers high doses in few fractions, precise dose delivery to target volumes and sufficient sparing of adjacent organs at risk (OARs) are required. Achieving these conflicting objectives is challenging for all patients receiving SBRT/SRS and may be particularly challenging when SBRT/SRS is adopted for treating patients with cardiac implantable electronic devices (CIEDs) because cumulative doses in CIEDs must be limited. Published research considering the different aspects of stereotactic treatment in patients with CIEDs was reviewed to summarise their findings in the following sections: (I) conventional linear accelerator (linac)-based SBRT and SRS; (II) CyberKnife, Gamma-Knife, VERO and helical tomotherapy SBRT and SRS; and (III) proton therapy. A total of 65 patients who had CIEDs and underwent SRS, SBRT, or SABR treatments were identified in the reviewed studies. The functionality of the CIEDs was assessed for 58 patients. Of those, CIED malfunctions (such as data loss, mode change, and inappropriate shock) were reported in four patients (6.89%). This review highlights the available sparse information in the literature by posing questions for future research.

Keywords

Stereotactic body radiotherapy (SBRT) Stereotactic radiosurgery (SRS) CyberKnife Gamma-knife Tomotherapy Pacemaker Implantable cardioverter defibrillator 

Notes

Acknowledgment

We would like to extend our gratitude to the director, coordinator, and board members in the Department of Medical Physics at the International Centre for Theoretical Physics (ICTP) for providing access to ICTP resources and databases. Sincere thanks to Dr. Recep Kandemir, medical physicist at Dokuz Eylul University, for his outstanding work in translation of reference#38. Also, special thanks go to the editor, and anonymous reviewers for their constructive comments and suggestions. The first author would like to acknowledge the financial support from University of Trieste and European Fund (FSE-S3/2, Project Code: FP1683026001) to perform this study.

Compliance with ethical standards

Conflict of interest

All the authors declare no conflict of interest.

Informed consent

Not applicable.

Research involving human participants and/or animals

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Australasian College of Physical Scientists and Engineers in Medicine 2019

Authors and Affiliations

  1. 1.Department of PhysicsUniversity of TriesteTriesteItaly
  2. 2.Physical SciencesPeter MacCallum Cancer CentreMelbourneAustralia
  3. 3.Italian National Institute of Nuclear Physics (INFN), sezione di TriesteTriesteItaly
  4. 4.Viterbi School of Biomedical EngineeringUniversity of Southern CaliforniaLos AngelesUSA
  5. 5.Medical Physics DepartmentAzienda Sanitaria Universitaria Integrata di TriesteTriesteItaly

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