Macromolecular Research

, Volume 26, Issue 13, pp 1219–1224 | Cite as

Transdermal Hydrogel Composed of Polyacrylic Acid Containing Propolis for Wound Healing in a Rat Model

  • Jin Kim
  • Chang-Moon LeeEmail author


The aim of this study was to investigate the effect of the Carbopol® hydrogel containing propolis (CHP) on wound healing in a rat model. CHP extracts inhibited nitric oxide production induced by lipopolysaccharide in RAW264.7 cells with a concentration-dependent manner. Wounds were prepared through excision to remove full-thickness skin of rats k]and then were covered with CHP. The covered wounds showed significantly rapid contraction and closure. Histological tissue examination indicated that CHP induced advanced granulation tissue formation and re-epithelialization in the wound. These results indicate that CHP may be helpful for the promotion of wound healing.


propolis hydrogel wound healing carbopol polyacrylic acid transdermal gel 


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Copyright information

© The Polymer Society of Korea and Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Advanced Chemicals and EngineeringChonnam National UniversityGwangjuKorea
  2. 2.Department of Biomedical EngineeringChonnam National UniversityYeosuKorea
  3. 3.Research Center of Healthcare Biomedical EngineeringChonnam National UniversityYeosuKorea

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