Macromolecular Research

, Volume 27, Issue 1, pp 48–54 | Cite as

Anticancer Activity of a New Chalcone Derivative-Loaded Polymeric Micelle

  • Young Jin Kim
  • Kang Pa Lee
  • Do Young Lee
  • Yun Tae Kim
  • Dongsoo Koh
  • Yoongho Lim
  • Myeong Sik YoonEmail author


Chalcones are hydrophobic polyphenols with extremely poor aqueous solubility. In this study, we prepared a new chalcone derivative-loaded nanoparticle (DPP-23-loaded NP) using a monomethoxy poly(ethylene glycol)-poly(D,L-lactide) copolymer which, in an aqueous environment, spontaneously forms a micellar formation with an average particle size of 20.8 nm. Exposure to various concentrations of DPP-23-loaded NP significantly diminished the cell viability of MCF-7 and MDA-MB-231 cells in a concentration-dependent manner. Our data show that DPP-23-loaded NP is a reliable drug delivery system, as observed by the fluorescein isothiocyanate (FITC) intensity accumulation in MDA-MB-231 cells.


chalcone cancer target drug delivery system nanoparticles MDA-MB-231 cell 


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Copyright information

© The Polymer Society of Korea and Springer Nature B.V. 2018

Authors and Affiliations

  • Young Jin Kim
    • 1
  • Kang Pa Lee
    • 3
  • Do Young Lee
    • 1
  • Yun Tae Kim
    • 1
  • Dongsoo Koh
    • 4
  • Yoongho Lim
    • 5
  • Myeong Sik Yoon
    • 1
    • 2
    Email author
  1. 1.Department of Pharmaceutical EngineeringHoseo UniversityAsan, ChungnamKorea
  2. 2.The Research Institute for Basic SciencesHoseo UniversityAsanKorea
  3. 3.Department of Medical Science, School of MedicineKonkuk UniversitySeoulKorea
  4. 4.Department of Applied ChemistryDongduk Women’s UniversitySeoulKorea
  5. 5.Division of Bioscience and BiotechnologyKonkuk UniversitySeoulKorea

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