Macromolecular Research

, Volume 26, Issue 12, pp 1129–1134 | Cite as

Facile Synthesis of Surfactant-Free Au Decorated Hollow Silica Nanoparticles for Photothermal Applications

  • Ju Ri Seo
  • Hyung Woo Choi
  • Da Eun Kim
  • Da Yeon Park
  • Eun-Joong Kim
  • Bong Geun ChungEmail author


We report herein a novel surfactant-free synthetic approach for hollow silica nanoparticles (HSN) loaded with Au nanocomposites (Au-HSN) to enhance photothermal properties. Transmission electron microscopy and elemental analysis confirmed the uniform HSN of Au nanoparticles. UV-vis spectroscopy and Fourier transform infrared spectroscopy were performed to demonstrate the dopamine (DA)-hyaluronate (HA) coating on Au-HSN. These nanocomposites dramatically increased up to 48 °C within few seconds under near-infrared irradiation. In addition, these Au-HSN/DA-HA nanoparticles showed the excellent endocytosis against cancer cells without any cytotoxicity. Therefore, it could be a powerful nanocarrier for tumor targeting and photothermal therapy applications.


hollow silica nanoparticle gold nanocomposite photothermal effect pH-responsive drug release 

Supplementary material

13233_2018_6143_MOESM1_ESM.pdf (226 kb)
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Copyright information

© The Polymer Society of Korea and Springer Nature B.V. 2018

Authors and Affiliations

  • Ju Ri Seo
    • 1
  • Hyung Woo Choi
    • 2
  • Da Eun Kim
    • 1
  • Da Yeon Park
    • 1
  • Eun-Joong Kim
    • 2
  • Bong Geun Chung
    • 3
    Email author
  1. 1.Department of Biomedical EngineeringSogang UniversitySeoulKorea
  2. 2.Research CenterSogang UniversitySeoulKorea
  3. 3.Department of Mechanical EngineeringSogang UniversitySeoulKorea

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