Granulosa Cell Tumor of the Ovary Accompanying with Ollier’s Disease: First Case of Contralateral Presentations

  • Amirmohsen Jalaeefar
  • Mohammad Shirkhoda
  • Amirsina SharifiEmail author
  • Mohsen Sfandbod
Case Report



Granulosa cell tumor (GCT) is a rare entity of ovarian malignancies. Juvenile GCT is considered a malignant tumor with an indolent course and tendency toward late recurrence. However, the association of this tumor and multiple enchondromas has been reported.

Case Presentation

A 17-year-old female with abnormal uterine bleeding was referred to our center. Ultrasonographic evaluation revealed a mass with origin in right ovary. Patient was worked up to undergo salpingo-oophorectomy, she felt a dull pain in her left lower limb. X-ray imaging was indicative for Ollier’s disease at the distal part of femur and proximal part of tibia. Postoperative pathological review was compatible with juvenile granulosa tumor of the right ovary.


This case was the first of its kind that ovarian tumor was contralateral to the side involved by enchondromatosis.


Granulosa cell tumor Ollier’s disease Maffucci syndrome Multiple enchondromatosis 


Compliance with Ethical Standards

Conflict of interest

All authors declare that there is no conflict of interest to disclose.

Human Participants and/or Animals

All parts of Declaration of Helsinki have been applied.

Informed Consent

The patient gave us written consent of her inclusion in the study.


  1. 1.
    Kottarathil VD, Antony MA, Nair IR, et al. Recent advances in granulosa cell tumor ovary: a review. Indian J Surg Oncol. 2013;4(1):37–47.Google Scholar
  2. 2.
    Park J-Y, Jin KL, Kim DY, et al. Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. Gynecol Oncol. 2012;125(1):80–6.Google Scholar
  3. 3.
    Colombo N, Parma G, Zanagnolo V, et al. Management of ovarian stromal cell tumors. J Clin Oncol. 2007;25(20):2944–51.Google Scholar
  4. 4.
    Brown J, Sood AK, Deavers MT, et al. Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? Gynecol Oncol. 2009;113(1):86–90.Google Scholar
  5. 5.
    Yu S, Zhou X, Hou B, et al. Metastasis of the liver with a granulosa cell tumor of the ovary: a case report. Oncol Lett. 2015;9(2):816–8.Google Scholar
  6. 6.
    Thirumala SD, Putti TC, Medalie NS, et al. Skeletal metastases from a granulosa-cell tumor of the ovary: report of a case diagnosed by fine-needle aspiration cytology. Diagn Cytopathol. 1998;19(5):375–7.Google Scholar
  7. 7.
    Piura B, Nemet D, Yanai‐Inbar I, et al. Granulosa cell tumor of the ovary: a study of 18 cases. J Surg Oncol. 1994;55(2):71–7.Google Scholar
  8. 8.
    Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. Cancer Treat Rev. 2008;34(1):1–12.Google Scholar
  9. 9.
    Tanaka Y, Sasaki Y, Nishihira H, et al. Ovarian juvenile granulosa cell tumor associated with Maffucci’s syndrome. Am J Clin Pathol. 1992;97(4):523–7.Google Scholar
  10. 10.
    Grenet P, Le GC, Badoual J, et al. Dyschondroplasia and ovarian tumor. Ann Pediatr (Paris). 1972;19(11):759–64.Google Scholar
  11. 11.
    Lewis RJ, Ketcham AS. Maffucci’s syndrome: functional and neoplastic significance case report and review of the literature. JBJS. 1973;55(7):1465–79.Google Scholar
  12. 12.
    Vaz RM, Turner C. Ollier disease (enchondromatosis) associated with ovarian juvenile granulosa cell tumor and precocious pseudopuberty. J Pediatr. 1986;108(6):945–7.Google Scholar
  13. 13.
    Asirvatham R, Rooney RJ, Watts HG. Ollier’s disease with secondary chondrosarcoma associated with ovarian tumour. Int Orthop. 1991;15(4):393–5.Google Scholar
  14. 14.
    Gell J, Stannard MW, Ramnani DM, et al. Juvenile Granulosa cell tumor in a 13-year-old girl with enchondromatosis (Oilier’s Disease): a case report. J Pediatr Adolesc Gynecol. 1998;11(3):147–50.Google Scholar
  15. 15.
    Rietveld L, Nieboer TE, Kluivers KB, et al. First case of juvenile granulosa cell tumor in an adult with Ollier disease. Int J Gynecol Pathol. 2009;28(5):464–7.Google Scholar
  16. 16.
    Hachi H, Othmany A, Douayri A, et al. Association d’une tumeur ovarienne de la granulosa juvénile à un syndrome de Maffucci. Gynécol Obstét Fertil. 2002;30(9):692–5.Google Scholar
  17. 17.
    Tamimi HK, Bolen JW. Enchondromatosis (Ollier’s disease) and ovarian juvenile granulosa cell tumor. A case report and review of the literature. Cancer. 1984;53(7):1605–8.Google Scholar
  18. 18.
    Pounder DJ, Iyer PV, Davy MLJ. Bilateral juvenile granulosa cell tumours associated with skeletal enchondromas. Aust N Z J Obstet Gynaecol. 1985;25(2):123–6.Google Scholar
  19. 19.
    Prat J, Oncology FCOG. Staging classification for cancer of the ovary, fallopian tube, and peritoneum. Int J Gynecol Obstet. 2014;124(1):1–5.Google Scholar
  20. 20.
    Burgetova A, Matejovsky Z, Zikan M, et al. The association of enchondromatosis with malignant transformed chondrosarcoma and ovarian juvenile granulosa cell tumor (Ollier disease). Taiwan J Obstet Gynecol. 2017;56(2):253–7.Google Scholar
  21. 21.
    Sugiyama M, Kohmoto Y, Miyoshi T, et al. In vivo and in vitro steroid bio-synthesis by ovarian juvenile granulosa cell tumor of a girl with Ollier’s disease. Acta Gynaecol Obstet Jpn. 1983;35(2):2185.Google Scholar
  22. 22.
    Velasco-Oses A, Alonso‐Alvaro A, Blanco‐Pozo A, et al. Ollier’s disease associated with ovarian juvenile granulosa cell tumor. Cancer. 1988;62(1):222–5.Google Scholar
  23. 23.
    Le CG, Bouvier R, Chappuis JP, et al. Ollier’s disease and juvenile ovarian granulosa tumor. Arch Fr Pediat. 1991;48(2):115–8.Google Scholar

Copyright information

© Federation of Obstetric & Gynecological Societies of India 2019

Authors and Affiliations

  • Amirmohsen Jalaeefar
    • 1
  • Mohammad Shirkhoda
    • 1
  • Amirsina Sharifi
    • 2
    Email author
  • Mohsen Sfandbod
    • 3
  1. 1.Department of Surgical Oncology, Cancer InstituteTehran University of Medical SciencesTehranIran
  2. 2.Sina Trauma and Surgery Research Center, Sina HospitalTehran University of Medical SciencesTehranIran
  3. 3.Tehran University of Medical SciencesTehranIran

Personalised recommendations