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3 Biotech

, 9:47 | Cite as

Dietary flavonoids inhibit the glycation of lens proteins: implications in the management of diabetic cataract

  • Kapil K. Patil
  • Rohan J. Meshram
  • Sagar H. Barage
  • Rajesh N. GaccheEmail author
Original Article
  • 16 Downloads

Abstract

The intervention of functional foods as complementary therapeutic approach for the amelioration of diabetes and sugar induced cataractogenesis is more appreciated over the present day chemotherapy agents owing to their nontoxic and increased bioavailability concerns. Dietary flavonoids, a class of bioactive phytochemicals is known to have wide range of biological activities against variety of human ailments. In the present study, we demonstrate anti-cataract effect of eight dietary flavonoids in sugar induced lens organ culture study. We present data on processes like inhibition of glycation-induced lens cloudiness, lens protein aggregation, glycation reaction and advanced glycation end products formation that can act as biochemical markers for this disease. The selected flavonoids were also tested for their aldose reductase (AR) inhibition (experimental and in silico). The molecular dynamics simulation results shed light on mechanistic details of flavonoid induced AR inhibition. The outcome of the present study clearly focuses the significance of kaempferol, taxifolin and quercetin as potential candidates for controlling diabetic cataract.

Keywords

Diabetic cataract Dietary flavonoids Glycation Aldose reductase Molecular docking Molecular dynamics 

Notes

Acknowledgements

Authors are thankful DST-SERB, New Delhi, for financial assistance and DRDP research grant of Savitribai Phule Pune University. KKP thanks DST-SERB for JRF.

Compliance with ethical standards

Conflict of interest

All contributing authors declare no conflicts of interest.

Supplementary material

13205_2019_1581_MOESM1_ESM.docx (1000 kb)
Supplementary material 1 (DOCX 1000 KB)

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Copyright information

© King Abdulaziz City for Science and Technology 2019

Authors and Affiliations

  • Kapil K. Patil
    • 1
  • Rohan J. Meshram
    • 2
  • Sagar H. Barage
    • 2
    • 4
  • Rajesh N. Gacche
    • 1
    • 3
    Email author
  1. 1.School of Life SciencesSwami Ramanand Teerth Marathwada UniversityNandedIndia
  2. 2.Bioinformatics CentreSavitribai Phule Pune UniversityPuneIndia
  3. 3.Department of BiotechnologySavitribai Phule Pune UniversityPuneIndia
  4. 4.Amity Institute of BiotechnologyAmity UniversityPanvelIndia

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