3 Biotech

, 9:57 | Cite as

Gold nanoparticle surface engineering strategies and their applications in biomedicine and diagnostics

  • Kuldeep Mahato
  • Sahil Nagpal
  • Mahero Ayesha Shah
  • Ananya Srivastava
  • Pawan Kumar Maurya
  • Shounak Roy
  • Amit Jaiswal
  • Renu Singh
  • Pranjal ChandraEmail author
Review Article


Gold nanoparticles (AuNPs) have found a wide range of biomedical and environmental monitoring applications (viz. drug delivery, diagnostics, biosensing, bio-imaging, theranostics, and hazardous chemical sensing) due to their excellent optoelectronic and enhanced physico-chemical properties. The modulation of these properties is done by functionalizing them with the synthesized AuNPs with polymers, surfactants, ligands, drugs, proteins, peptides, or oligonucleotides for attaining the target specificity, selectivity and sensitivity for their various applications in diagnostics, prognostics, and therapeutics. This review intends to highlight the contribution of such AuNPs in state-of-the-art ventures of diverse biomedical applications. Therefore, a brief discussion on the synthesis of AuNPs has been summarized prior to comprehensive detailing of their surface modification strategies and the applications. Here in, we have discussed various ways of AuNPs functionalization including thiol, phosphene, amine, polymer and silica mediated passivation strategies. Thereafter, the implications of these passivated AuNPs in sensing, surface-enhanced Raman spectroscopy (SERS), bioimaging, drug delivery, and theranostics have been extensively discussed with the a number of illustrations.


Gold nanoparticles Synthesis approaches Surface functionalization strategies Biomedical applications 



This work is supported by Science and Engineering Research Board (SERB) project file no. ECR/2016/000100.

Compliance with ethical standards

Conflict of interest

Authors report no conflict of interest in this work.


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Copyright information

© King Abdulaziz City for Science and Technology 2019

Authors and Affiliations

  • Kuldeep Mahato
    • 1
  • Sahil Nagpal
    • 2
  • Mahero Ayesha Shah
    • 3
  • Ananya Srivastava
    • 4
  • Pawan Kumar Maurya
    • 5
  • Shounak Roy
    • 6
  • Amit Jaiswal
    • 6
  • Renu Singh
    • 7
  • Pranjal Chandra
    • 1
    Email author
  1. 1.Laboratory of Bio-Physio Sensors and Nanobioengineering, Department of Bioscience and BioengineeringIndian Institute of TechnologyGuwahatiIndia
  2. 2.Technische Universität DresdenDresdenGermany
  3. 3.Julius Maximilians Universität Würzburg, Faculty of medicine UniklinikWürzburgGermany
  4. 4.Department of Pharmacology and ToxicologyNational Institute of Pharmaceutical Education and ResearchGuwahatiIndia
  5. 5.Department of BiochemistryCentral University of Haryana MahendergarhHaryanaIndia
  6. 6.School of Basic SciencesIndian Institute of Technology MandiMandiIndia
  7. 7.Department of Bioproducts and Biosystems EngineeringUniversity of MinnesotaSaint PaulUSA

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