Simple fabrication of sericin/graphene nanocomposites for application in articular cartilage repair in knee joints in nursing care

  • Yanrong Yuan
  • Haizhen Liu
  • Na Zheng
  • Linggong Gao
  • Feiyan Liu
  • Guofeng Guan
  • Guilan ZhangEmail author
Original Article


In the present work, sericin/reduced graphene oxide (SSG) nanocomposites are synthesized through a low cost, facile and biological approach. An anticipated amount of sericin powder was mixed to GO dispersion with sericin/GO ratios of 10:1, 50:1, and 100:1 to obtain sericin/rGO nanocomposites such as SSG10, SSG50, and SSG100, respectively. TEM images revealed the rough surface of graphene sheets with obtained proteins assembled on the surface of the GO nanosheets. Further, biological studies revealed that SSG nanocomposites significantly promoted the collagen levels and glycosaminoglycan. Cell proliferation results showed the effective growth of MSCs with SSG100 than GO, SSG10, and SSG50. Also, the confocal microscopic images exhibited the spindle-like morphology of MSCs with uniform size and increased cell density on the 5th day of cell proliferation in case of SSG100 than GO and other nanocomposites. Therefore, the present results suggest that the fabricated SSG hybrid material could act as promising candidates for future applications of repairing articular cartilage in knee joints in nursing care.


Sericin Graphene oxide Knee joints 



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Copyright information

© King Abdulaziz City for Science and Technology 2019

Authors and Affiliations

  • Yanrong Yuan
    • 1
  • Haizhen Liu
    • 2
  • Na Zheng
    • 3
  • Linggong Gao
    • 4
  • Feiyan Liu
    • 1
  • Guofeng Guan
    • 1
  • Guilan Zhang
    • 4
    • 5
    Email author
  1. 1.Department of Foot and Ankle SurgeryBinzhou Medical University HospitalBinzhouChina
  2. 2.Nursing DepartmentShi Kou Central HospitalDongyingChina
  3. 3.The Third Department of PsychiatryBinzhou People’s HospitalBinzhouChina
  4. 4.Department of Reproductive MedicineBinzhou Medical University HospitalBinzhouChina
  5. 5.Department of Hand (Micro) SurgeryBinzhou Medical University HospitalBinzhouChina

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