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Cytotoxicity of functionalized iron oxide nanoparticles coated with rifampicin and tetracycline hydrochloride on Escherichia coli and Staphylococcus aureus

  • Nidhi Prakash
  • Madeeha Sadaf
  • A. Salomi
  • Elcey C. DanielEmail author
Original Article

Abstract

Nanotechnology and its progress are paving the way in field of biomedical sciences and showing its utility from classic period. Various nanomaterials are extensively used to load drugs such as curcumin and antibiotics. Iron oxide as drug delivery system is studied for its ability to target the specific site to deliver the drug and reduce its side effects. The work was focused on the synthesis of iron oxide by chemical co-precipitation method. The particles functionalized with surfactants, Tween80 and CTAB, for stabilization were coated with broad spectrum antibiotics, rifampicin and tetracycline hydrochloride. These synthesized and coated iron oxide particles were characterized by SEM, UV–Vis, and FTIR. The release of the individual drugs from the nanoparticles was confirmed based on the growth inhibition of Escherichia coli and Staphylococcus aureus using agar well diffusion method and optical density.

Keywords

Co-precipitation method Antibiotics Antibacterial activity SEM FTIR 

Notes

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Copyright information

© King Abdulaziz City for Science and Technology 2019

Authors and Affiliations

  • Nidhi Prakash
    • 1
  • Madeeha Sadaf
    • 1
  • A. Salomi
    • 1
  • Elcey C. Daniel
    • 1
    Email author
  1. 1.Kristu Jayanti College (Autonomous)BengaluruIndia

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