Evaluation of Iron Status in Patients of Solid Organ Malignancies: Study from a Cancer Research Centre
Anemia associated with cancer is a major public health issue. The gravity of this problem is likely to be higher in India due to already existing malnutrition in the general population. Iron deficiency anemia (IDA) as a subset has not been evaluated in Indian population of cancer patients. This study was undertaken to evaluate iron status among newly diagnosed advanced-stage cancer patients with anemia at a cancer research institute in India. Sixty-four patients of anemia were identified who fulfilled the inclusion criteria. Iron status was noted. Absolute iron deficiency (AID) was identified in 8 (12.5%) patients. Functional iron deficiency (FID) was seen in 48 (75%) patients. Probable functional iron deficiency (PFID) was seen in 2 (3.1%) patients while no iron deficiency (NID) was seen in 6 (9.3%) patients. FID is seen in majority of advanced-stage solid organ cancer patients in India. Large sample studies are required to better define the exact prevalence of iron deficiency, chemotherapy-induced anemia, and anemia in cancer subtypes.
KeywordsAnemia in cancer Iron deficiency anemia Functional iron deficiency
DS, LA, and RS were involved in the data collection. PPN, MW, and DS wrote the manuscript. DS and LA reviewed the final manuscript.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflicts of interest.
- 9.Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 [Online]. 2017 Nov 27[cited 2017 Nov 27]; Available from: URL: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_5x7.pdf
- 10.National Comprehensive Cancer Network. NCCN practice guidelines in oncology; Cancer and Chemotherapy-Induced Anemia – V2.2018. Available at http://www.nccn.org/professionals/physician_gls/pdf/anemia.pdf
- 12.National Cancer Institute Anemia Scale. Adapted from the Common Terminology Criteria for Adverse Events. Available at: http://evs.nci.nih.gov/ftp1/CTCAE/About.html