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Salivary Duct Carcinoma of Parotid Gland: a Rare Tumor

  • Giridhar Chidananda-MurthyEmail author
  • Jayanthi Chandran
Case Report
  • 2 Downloads

Introduction

Tumors of the salivary gland account for 3–4% of all head and neck malignancies [1]. About 70–90% of these tumors are located in parotid gland of which majority are benign and only 15% are malignant [1]. Mucoepidermoid carcinoma is the most common salivary gland malignancy followed by carcinoma ex-pleomorphic adenoma and acinic cell carcinoma. Other malignant tumors include adenoid cystic carcinoma, adenocarcinoma, squamous cell carcinoma, and poorly differentiated carcinoma [2]. Lymphoma of salivary glands is rare and commonly involves parotid gland. Parotid gland can harbor metastases to intraparotid nodes from tumors involving upper face particularly temple area and external auditory canal.

Salivary duct carcinoma (SDC) is an uncommon malignancy of salivary gland that arises from ductal epithelial cells with a reported incidence of 1–3% [3, 4]. It most commonly occurs in parotid gland [4, 5, 6, 7]. It is known for a very aggressive behavior with early involvement of...

Notes

References

  1. 1.
    Eveson JW, Cawson RA (1985) Salivary gland tumours. A review of 2410 cases with particular reference to histological types, site, age and sex distribution. J Pathol 146(1):51–58CrossRefGoogle Scholar
  2. 2.
    Kane WJ, McCaffrey TV, Olsen KD, Lewis JE (1991) Primary parotid malignancies: a clinical and pathologic review. Arch Otolaryngol Head Neck Surg 117(3):307–315CrossRefGoogle Scholar
  3. 3.
    Barnes L, Rao U, Krause J, Contis L, Schwartz A, Scalamogna P (1994) Salivary duct carcinoma: part I. A clinicopathologic evaluation and DNA image analysis of 13 cases with review of the literature. Oral surgery, oral medicine. Oral Pathol 78(1):64–73CrossRefGoogle Scholar
  4. 4.
    Jaehne M, Roeser K, Jaekel T, Schepers JD, Albert N, Löning T (2005) Clinical and immunohistologic typing of salivary duct carcinoma. Cancer 103(12):2526–2533CrossRefGoogle Scholar
  5. 5.
    Lewis JE, McKinney BC, Weiland LH, Ferreiro JA, Olsen KD (1996) Salivary duct carcinoma: clinicopathologic and immunohistochemical review of 26 cases. Cancer 77(2):223–230CrossRefGoogle Scholar
  6. 6.
    Delgado R, Vuitch F, Albores-Saavedra J (1993) Salivary duct carcinoma. Cancer 72(5):1503–1512CrossRefGoogle Scholar
  7. 7.
    Guzzo M, Palma SD, Grandi C, Molinari R (1997) Salivary duct carcinoma: clinical characteristics and treatment strategies. Head Neck 19(2):126–133CrossRefGoogle Scholar
  8. 8.
    Kleinsasser O (1968) Speichelgang-carcinome, Eine den milchgangcarcinomen der Brustdruse analoge Gruppe von Speicheldrusentumoren. Arch Klin Exp Ohren Nasen Kehlkopfheikd 192:100–105CrossRefGoogle Scholar
  9. 9.
    Lee YY, Wong KT, King AD, Ahuja AT (2008) Imaging of salivary gland tumours. Eur J Radiol 66(3):419–436CrossRefGoogle Scholar
  10. 10.
    Yousem DM, Kraut MA, Chalian AA (2000) Major salivary gland imaging. Radiology 216(1):19–29CrossRefGoogle Scholar
  11. 11.
    Motoori K, Iida Y, Nagai Y, Yamamoto S, Ueda T, Funatsu H, Ito H, Yoshitaka O (2005) MR imaging of salivary duct carcinoma. Am J Neuroradiol 26(5):1201–1206PubMedGoogle Scholar
  12. 12.
    O'Dwyer P, Farrar WB, James AG, Finkelmeier W, McCabe DP (1986) Needle aspiration biopsy of major salivary gland tumors: its value. Cancer 57(3):554–557CrossRefGoogle Scholar
  13. 13.
    Skalova A, Starek I, Vanecek T, Kucerova V, Plank L, Szepe P, Di Palma S, Leivo I (2003) Expression of HER-2/neu gene and protein in salivary duct carcinomas of parotid gland as revealed by fluorescence in-situ hybridization and immunohistochemistry. Histopathology 42(4):348–356CrossRefGoogle Scholar
  14. 14.
    Hosal AS, Fan C, Barnes L, Myers EN (2003) Salivary duct carcinoma. Otolaryngol Head Neck Surg 129(6):720–725CrossRefGoogle Scholar
  15. 15.
    Nasser SM, Faquin WC, Dayal Y (2003) Expression of androgen, estrogen, and progesterone receptors in salivary gland tumors: frequent expression of androgen receptor in a subset of malignant salivary gland tumors. Am J Clin Pathol 119(6):801–806CrossRefGoogle Scholar
  16. 16.
    Nabili V, Tan JW, Bhuta S, Sercarz JA, Head CS (2007) Salivary duct carcinoma: a clinical and histologic review with implications for trastuzumab therapy. Head Neck 29(10):907–912CrossRefGoogle Scholar
  17. 17.
    Limaye SA, Posner MR, Krane JF, Fonfria M, Lorch JH, Dillon DA, Shreenivas AV, Tishler RB, Haddad RI (2013) Trastuzumab for the treatment of salivary duct carcinoma. Oncologist 18(3):294–300CrossRefGoogle Scholar
  18. 18.
    Kapadia SB, Barnes L (1998) Expression of androgen receptor, gross cystic disease fluid protein, and CD44 in salivary duct carcinoma. Mod Pathol 11(11):1033–1038PubMedGoogle Scholar
  19. 19.
    Fan CY, Wang J, Barnes EL (2000) Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma: an immunohistochemical analysis of 13 cases and review of the literature. Am J Surg Pathol 24(4):579–586CrossRefGoogle Scholar
  20. 20.
    Simpson RH (2013) Salivary duct carcinoma: new developments—morphological variants including pure in situ high grade lesions; proposed molecular classification. Head and Neck Pathology 7(1):48–58CrossRefGoogle Scholar
  21. 21.
    Gnepp DR (1991) Metastatic disease to the major salivary gland. In: Ellis GL, Auclair PL, Gnepp DR (ed) Surgical pathology of the salivary glands, 1st edn. WB Saunders, Philadelphia, pp 560–569Google Scholar
  22. 22.
    Delgado R, Klimstra D, Albores-Saavedra J (1996) Low grade salivary duct carcinoma: a distinctive variant with a low grade histology and a predominant intraductal growth pattern. Cancer 78(5):958–967CrossRefGoogle Scholar

Copyright information

© Indian Association of Surgical Oncology 2018

Authors and Affiliations

  1. 1.Department of Surgical OncologySri Venkateshwaraa Medical College & HospitalPuducherryIndia
  2. 2.Department of PathologySri Venkateshwaraa Medical College & HospitalPuducherryIndia

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