Advertisement

Neuroendocrine Carcinoma of Duodenum—an Uncommon Tumour at an Unusual Site

  • Palki Dewan
  • Shubha P. Bhat
  • H. L. Kishan Prasad
  • Rajesh Ballal
  • K. Sajitha
Case Report
  • 1 Downloads

Abstract

Neuroendocrine carcinoma rarely occurs in the duodenum, and most cases of neuroendocrine carcinoma in the duodenum show rapid progression of the disease. Such cases have poor prognosis even with radical surgery with or without chemotherapy with low 5-year survival rate. We present a case of a 52-year-old man who presented with abdominal pain of 1-month duration and one episode of vomiting. Upper gastrointestinal endoscopy revealed polypoidal lesions in the first and second part of the duodenum. Whipple’s procedure was performed. Diagnosis of poorly differentiated neuroendocrine carcinoma was made with extension to pancreas with peripancreatic lymph node metastases. The patient expired on post operative day 17 following cardiac arrest.

Keywords

Neuroendocrine tumour Duodenum Pancreaticoduodenectomy 

Notes

References

  1. 1.
    Sata N, Tsukahara M, Koizumi M, Yoshizawa K, Kurihara K, Nagai H, Someya T, Saito K (2004) Primary small-cell neuroendocrine carcinoma of the duodenum – a case report and review of literature. World Journal of Surgical Oncology 2:28.  https://doi.org/10.1186/1477-7819-2-28. CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Uppin MS, Uppin SG, Sunil CS, Hui M, Paul TR, Bheerappa N (2017) Clinicopathologic study of neuroendocrine tumors of gastroenteropancreatic tract: a single institutional experience. J Gastrointest Oncol 8(1):139–147CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Kim SH, Park CH, Ki HS, Jun CH, Park SY, Kim HS, Choi SK, Rew JS (2013) Endoscopic treatment of duodenal neuroendocrine tumors. Clinical Endoscopy 46(6):656–661.  https://doi.org/10.5946/ce.2013.46.6.656 CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Qui X, Liu M, Liu M, Yang Z, Liu J, Meng F et al (2017) Analysis of primary site and pathology on 903 patients with neuroendocrine neoplasms. Chinese journal of gastrointestinal Surgery 20(9):993Google Scholar
  5. 5.
    Chin JL, O’Toole D (2017) Diagnosis and management of upper gastrointestinal neuroendocrine tumors. Clinical Endoscopy 50(6):520–529.  https://doi.org/10.5946/ce.2017.181 CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Strinovic M, Kruljac I, Dabelic N, Nikolic M, Ljubicic N, Cugura JF (2016) Duodenal neuroendocrine tumors (d-NETs): challenges in diagnosis and treatment. Endocrine Oncology and Metabolism 2(3):174–93Google Scholar
  7. 7.
    Scherübl H, Jensen RT, Cadiot G, Stölzel U, Klöppel G (2010) Neuroendocrine tumors of the small bowels are on the rise: early aspects and management. World J Gastrointest Endosc 2(10):325–334CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Yang K, Kim S, Shin N, Park Y (2017) Clinicopathological features and surgical outcomes of neuroendocrine tumors of ampulla of Vater. BMC Gastroenterol 17:70CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Imamura N, Nanashima A, Hiyoshi M, Fujii Y (2017) Report of two cases of large cell neuroendocrine carcinoma of duodenal ampulla with contrasting outcomes following pancreaticoduodenectomy according to the use of adjuvant chemotherapy. Int J Surg Case Rep 31:132–138.  https://doi.org/10.1016/j.ijscr.2017.01.031 CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Freis P, Graillot E, Rousset P, Hervieu V, Chardon L, Walter T (2017) Prognostic factors in neuroendocrine carcinoma: biological markers are more useful than histomorphological markers ; Vol 7: 40609Google Scholar
  11. 11.
    Vanoli A, La Rosa S, Klersy C, Grillo F, Albarello L, Inzani F, Maragliano R, Manca R, Luinetti O, Milione M, Doglioni C, Rindi G, Capella C, Solcia E (2017) Four neuroendocrine tumor types and neuroendocrine carcinoma of the duodenum: analysis of 203 cases. Neuroendocrinology 104:112–125CrossRefGoogle Scholar

Copyright information

© Indian Association of Surgical Oncology 2018

Authors and Affiliations

  • Palki Dewan
    • 1
  • Shubha P. Bhat
    • 1
  • H. L. Kishan Prasad
    • 1
  • Rajesh Ballal
    • 1
  • K. Sajitha
    • 1
  1. 1.K.S. Hegde Medical AcademyNITTE - Deemed to be UniversityMangaloreIndia

Personalised recommendations