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Nuclear Medicine and Molecular Imaging

, Volume 53, Issue 4, pp 242–246 | Cite as

Theranostics Based on Liposome: Looking Back and Forward

  • Wooseung Lee
  • Hyung-Jun ImEmail author
Perspective
  • 36 Downloads

Abstract

Liposome is one of the oldest yet most successful nanomedicine platforms. Doxil®, PEGylated liposome loaded with doxorubicin (DOX), was approved by the FDA in 1995 for the treatment of AIDS-related Kaposi’s sarcoma, and it was the first approval for nanomedicine. Since then, liposome-based therapeutics were approved for the treatment of various diseases and many clinical trials are underway. The success of the liposome-based therapeutics was due to following factors: (1) ease of synthesis, (2) biocompatibility, (3) the ability to load both hydrophilic and hydrophobic agents, and (4) long circulation property after application of polyethylene glycol (PEG). Recently, more functionalities are introduced to liposome platform, which are (1) in vivo imaging probes for optical, magnetic resonance imaging (MRI), positron emission tomography (PET), and single-photon emission computed tomography (SPECT), (2) pH and temperature-sensitive lipid moiety, and (3) novel agents for photodynamic and photothermal therapies (PDT, PTT). These conventional and newly tested advantages make the liposome to be one of the most promising nanoplatforms for theranostics.

Keywords

Liposome Theranostics Nanomedicine Controlled drug release 

Notes

Funding Information

This study was supported by Research Resettlement Fund for the new faculty of Seoul National University, the National Research Foundation of Korea (NRF) (NRF-2017R1D1A1B03035556 and NRF-2019M2D2A1A01058210), and the Ministry of Health and Welfare Korea (HI18C0886 and HI19C0339).

Compliance with Ethical Standards

Conflict of Interest

Wooseung Lee and Hyung-Jun Im declare that they have no conflict of interest.

Ethical Approval

This work does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

Not applicable.

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Copyright information

© Korean Society of Nuclear Medicine 2019

Authors and Affiliations

  1. 1.Department of Transdisciplinary Studies, Graduate School of Convergence Science and TechnologySeoul National UniversitySeoulRepublic of Korea

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