Nuclear Medicine and Molecular Imaging

, Volume 52, Issue 5, pp 398–400 | Cite as

Evidence of Subclavian Vein Thrombosis on First-Pass 18FDG PET in a Patient with Relapsing Upper Mediastinum Lymphoma

  • Fayçal Ben BouallègueEmail author
  • Fabien Vauchot
  • Denis Mariano-Goulart
Interesting Image


Baseline 18F-FDG PET was performed in a 74-year-old patient with relapsing upper mediastinum lymphoma. Left subclavian thrombosis was suspected on prior contrast-enhanced CT. Dynamic PET imaging was achieved during 3 min after IV injection of 18F-FDG to the left arm in order to further assess left subclavian vein permeability. The 20-s dynamic frame at 1 min after injection confirmed the absence of flow in the left subclavian vein and evidenced the derivation of 18F-FDG through left axillary, then superficial, then right internal mammary collaterals to the superior vena cava, hence confirming the subclavian thrombosis.


FDG PET First-pass Deep vein thrombosis Lymphoma 


Compliance with Ethical Standards

Conflict of Interest

Fayçal Ben Bouallègue, Fabien Vauchot, and Denis Mariano-Goulart declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.


  1. 1.
    Falanga A, Marchetti M. Venous thromboembolism in the hematologic malignancies. J Clin Oncol. 2009;27:4848–57.CrossRefPubMedGoogle Scholar
  2. 2.
    Karande GY, Hedgire SS, Sanchez Y, Baliyan V, Mishra V, Ganguli S, et al. Advanced imaging in acute and chronic deep vein thrombosis. Cardiovasc Diagn Ther. 2016;6:493–507.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Khosa F, Otero HJ, Prevedello LM, Rybicki FJ, Di Salvo DN. Imaging presentation of venous thrombosis in patients with cancer. AJR Am J Roentgenol. 2010;194:1099–108.CrossRefPubMedGoogle Scholar
  4. 4.
    Seabold JE. Radionuclide venography and labeled platelets in deep venous thrombosis. Semin Nucl Med. 2001;31:124–8.CrossRefPubMedGoogle Scholar
  5. 5.
    Houshmand S, Salavati A, Hess S, Ravina M, Alavi A. The role of molecular imaging in diagnosis of deep vein thrombosis. Am J Nucl Med Mol Imaging. 2014;4:406–25.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Rondina MT, Lam UT, Pendleton RC, Kraiss LW, Wanner N, Zimmerman GA, et al. (18)F-FDG PET in the evaluation of acuity of deep vein thrombosis. Clin Nucl Med. 2012;37:1139–45.PubMedPubMedCentralGoogle Scholar
  7. 7.
    Hess S, Madsen PH, Iversen ED, Frifelt JJ, Hoilund-Carlsen PF, Alavi A. Efficacy of FDG PET/CT imaging for venous thromboembolic disorders: preliminary results from a prospective, observational pilot study. Clin Nucl Med. 2015;40:e23–6.CrossRefPubMedGoogle Scholar
  8. 8.
    Le Roux PY, Robin P, Delluc A, Tardy B, Abgral R, Couturaud F, et al. Performance of 18F fluoro-2-désoxy-D-glucose positron emission tomography/computed tomography for the diagnosis of venous thromboembolism. Thromb Res. 2015;135:31–5.CrossRefPubMedGoogle Scholar
  9. 9.
    Zhu HJ, Hess S, Rubello D, Goris ML, Alavi A. The strong but nonspecific relationship between 18F-FDG uptake in the lower-extremity veins and venous thromboembolism. Nucl Med Commun. 2016;37:322–8.PubMedGoogle Scholar

Copyright information

© Korean Society of Nuclear Medicine 2018

Authors and Affiliations

  1. 1.Nuclear Medicine DepartmentMontpellier University HospitalMontpellierFrance
  2. 2.PhyMedExp, INSERM, CNRS, Montpellier UniversityMontpellierFrance
  3. 3.Nuclear medicine departmentLapeyronie University HospitalMontpellier Cedex 5France

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