Tracer Accumulation in Relation to Venous Thrombus on 18F-DOPA PET/CT in a Case of Persistent Hyperinsulinemic Hypoglycemia of Infancy

  • Saurabh Arora
  • Nishikant Avinash DamleEmail author
  • Averilicia Passah
  • Rajni Sharma
  • Harish Goyal
  • Shreedharan Thankarajan Arunraj
  • Priyanka Gupta
  • Manisha Jana
Case Report


18F-DOPA PET/CT is commonly done in patients with persistent hyperinsulinemic hypoglycemia of infancy (PHHI) to look for any focal lesion in the pancreas. We present the findings in a 20-day-old neonate with PHHI who underwent 18F-DOPA PET/CT. The scan showed diffuse uptake in the pancreas with no focal lesion, physiologic excretion into the genito-urinary system, and interestingly tracer accumulation was seen in the inferior vena cava and ilio-femoral veins which is a non-physiological site for tracer accumulation. The uptake corresponded to a large venous thrombus which was confirmed by a venous Doppler.


Venous thrombus 18F-DOPA PET/CT Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) Congenital hyperinsulinism 


Compliance with Ethical Standards

Conflict of Interest

Saurabh Arora, Nishikant Avinash Damle, Averilicia Passah, Rajni Sharma, Harish Goyal, Shreedharan Thankarajan Arunraj, Priyanka Gupta, and Manisha Jana declare that they have no conflict of interest.

Ethical Approval Statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent from parents of neonate was obtained to be included in the study.


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Copyright information

© Korean Society of Nuclear Medicine 2019

Authors and Affiliations

  • Saurabh Arora
    • 1
  • Nishikant Avinash Damle
    • 1
    Email author
  • Averilicia Passah
    • 1
  • Rajni Sharma
    • 2
  • Harish Goyal
    • 1
  • Shreedharan Thankarajan Arunraj
    • 1
  • Priyanka Gupta
    • 2
  • Manisha Jana
    • 3
  1. 1.Department of Nuclear MedicineAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of Paediatric EndocrinologyAll India Institute of Medical SciencesNew DelhiIndia
  3. 3.Department of RadiodiagnosisAll India Institute of Medical SciencesNew DelhiIndia

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