Journal of Physiology and Biochemistry

, Volume 75, Issue 3, pp 241–251 | Cite as

About the controversies of the cardioprotective effect of n-3 polyunsaturated fatty acids (PUFAs) between animal studies and clinical meta-analyses: a review with several strategies to enhance the beneficial effects of n-3 PUFAs

  • Luc DemaisonEmail author
  • Thibault Leger
  • Catherine Vergely
  • Luc Rochette
  • Kasra Azarnoush
Original Article


Several meta-analyses describing the effect of n-3 polyunsaturated fatty acids on the survival rate of the victims of an acute coronary event do not clearly support a beneficial impact of these fatty acids. Yet, animal studies consistently show n-3 PUFA–induced protection against ischemia-reperfusion-induced myocardial injuries. The impact on reperfusion arrhythmias of these PUFAs is more controversial. The literature shows the anti-arrhythmic properties of circulating n-3 PUFAs. However, when these fatty acids are incorporated in the cardiac membrane, they protect the myocardial tissue vis a vis cellular damage but they can be either pro- or anti-arrhythmic during reperfusion, depending on the severity of tissue injuries. The latter elements can explain the lack of beneficial effect observed in the meta-analyses, but a proper use of n-3 PUFAs may provide advantages in terms of survival rate. This review discusses the different results obtained in humans and animals and presents several strategies to enhance the beneficial effects of n-3 PUFAs.


N-3 PUFAs Heart Infarction Cellular damages Arrhythmias Cardiac death 



We would like to thank Christophe Cottet for his skillful English editing of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Agronomical Research.


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© University of Navarra 2019

Authors and Affiliations

  1. 1.INRA, UNH, Unité de Nutrition HumaineUniversité Clermont AuvergneClermont-FerrandFrance
  2. 2.Research team Pathophysiology and Epidemiology of Cerebro-Cardiovascular Diseases (PEC2, EA7460)University of Bourgogne Franche-Comté, UFR des Sciences de SantéDijonFrance
  3. 3.Heart Surgery Department, G. Montpied HospitalClermont-Ferrand University HospitalClermont-FerrandFrance

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