The role of lamin A/C in mesenchymal stem cell differentiation

  • Bo Zhang
  • Yang Yang
  • Reziwan Keyimu
  • Jin Hao
  • Zhihe ZhaoEmail author
  • Rui YeEmail author


Lamin A/C is the major architectural protein of cell nucleus in charge of the nuclear mechanosensing. By integrating extracellular mechanical and biochemical signals, lamin A/C regulates multiple intracellular events including mesenchymal stem cell (MSC) fate determination. Herein, we review the recent findings about the effects and mechanisms of lamin A/C in governing MSC lineage commitment, with a special focus on osteogenesis and adipogenesis. Better understanding of MSC differentiation regulated by lamin A/C could provide insights into pathogenesis of age-related osteoporosis.


Lamin A/C Mesenchymal stem cells Osteogenesis Adipogenesis 



Extracellular matrix


Hutchinson-Gilford progeria syndrome


Klarsicht/ANC-1/Syne homology


Linkers of nucleoskeleton and cytoskeleton


Megakaryoblastic leukemia 1


Mesenchymal stem cell


Retinoic acid


Retinoic acid receptors


RA-responsive elements


Serum response factor




Yes-associated protein


transcriptional co-activators with PDZ-binding motif


Funding information

This work was supported by grants from the National Natural Science Foundation of China (31470904, Zhihe Zhao; 81400522, Rui Ye).


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Copyright information

© University of Navarra 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of StomatologySichuan UniversityChengduChina
  2. 2.Department of Orthodontics, West China Hospital of StomatologySichuan UniversityChengduChina
  3. 3.Department of General Dentistry, West China Hospital of StomatologySichuan UniversityChengduChina
  4. 4.Program in Biological Sciences in Dental MedicineHarvard School of Dental MedicineBostonUSA

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