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Increased Cerebral Oxygen Metabolism and Ischemic Stress in Subjects with Metabolic Syndrome-Associated Risk Factors: Preliminary Observations

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Abstract

Hypertension, diabetes, obesity, and dyslipidemia are risk factors that characterize metabolic syndrome (MetS), which increases the risk for stroke by 40%. In a preliminary study, our aim was to evaluate cerebrovascular reactivity and oxygen metabolism in subjects free of vascular disease but with one or more of these risk factors. Volunteers (n = 15) 59 ± 15 (mean ± SD) years of age clear of cerebrovascular disease by magnetic resonance angiography but with one or more risk factors were studied by quantitative positron emission tomography for measurement of cerebral blood flow, oxygen consumption, oxygen extraction fraction (OEF), and acetazolamide cerebrovascular reactivity. Eight of ten subjects with MetS risk factors had OEF >50%. None of the five without risk factors had OEF >50%. The presence of MetS risk factors was highly correlated with OEF >50% by Fisher's exact test (p < 0.007). The increase in OEF was significantly (P < 0.001) correlated with cerebral metabolic rate for oxygen. Increased OEF was not associated with compromised acetazolamide cerebrovascular reactivity. Subjects with one or more MetS risk factors are characterized by increased cerebral oxygen consumption and ischemic stress, which may be related to increased risk of cerebrovascular disease and stroke.

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Acknowledgements

No other persons have made substantial contributions to this manuscript. This work was supported by NIH grants Nos. NS051639 and NS061216.

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Authors and Affiliations

  1. Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Donald Sashin & Fernando Boada

  2. Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Ridwan Lin, Syed F. Zaidi, Maxim D. Hammer, Vivek Reddy, Tudor G. Jovin, Mouhammad Jumaa & Julia Billigen

  3. Departments of Neurology, Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Lori Massaro

  4. Department of Neurology, St. Louis University Hospital, Saint Louis, MO, USA

    Nirav Vora

  5. Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Nicholas Bircher

  6. Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Yue-Fang Chang

  7. Department of Radiology, Johns Hopkins University, Baltimore, MD, USA

    Hiroto Kuwabara

  8. Cerebrovascular Center, Cleveland Clinic, Cleveland, OH, USA

    Ken Uchino

  9. Department of Neurosurgery, University of New Mexico, Domenici Hall/BRaIN Center, Room 1131B, 1101 Yale Blvd, Albuquerque, NM, 87131, USA

    Howard Yonas & Edwin M. Nemoto

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  1. Ken Uchino
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Correspondence to Edwin M. Nemoto.

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Uchino, K., Lin, R., Zaidi, S.F. et al. Increased Cerebral Oxygen Metabolism and Ischemic Stress in Subjects with Metabolic Syndrome-Associated Risk Factors: Preliminary Observations. Transl. Stroke Res. 1, 178–183 (2010). https://doi.org/10.1007/s12975-010-0028-2

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  • DOI: https://doi.org/10.1007/s12975-010-0028-2

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