Cardiovascular Intervention and Therapeutics

, Volume 33, Issue 2, pp 163–168 | Cite as

Comparison of early-phase arterial repair following cobalt-chrome everolimus-eluting stent and slow-release zotarolimus-eluting stent: an angioscopic study

  • Takayuki Ishihara
  • Osamu Iida
  • Masashi Fujita
  • Masaharu Masuda
  • Shin Okamoto
  • Kiyonori Nanto
  • Takashi Kanda
  • Takuya Tsujimura
  • Akihiro Sunaga
  • Masaki Awata
  • Shinsuke Nanto
  • Masaaki Uematsu
Original Article
First Online:
Received:
Accepted:

Abstract

Whether arterial repair following implantation of drug-eluting stents (DES) of the second generation differs among stent types remains unknown. We examined 41 DES placed in 28 patients (age 72 ± 7 years, male 89%) presenting with stable angina pectoris due to de novo lesions in native coronary arteries. Coronary angioscopy was performed 4 ± 1 months after stent implantation. Patients were divided into two groups based on the DES types: 22 cobalt-chrome everolimus-eluting stents (CoCr-EES) in 13 patients and 19 slow-release zotarolimus-eluting stents (R-ZES) in 15 patients. Neointimal coverage (NIC) was graded as: grade 0, stent struts exposed; grade 1, struts bulging into the lumen, although covered; grade 2, struts embedded in the neointima, but translucent; grade 3, struts fully embedded and invisible. NIC was defined as heterogeneous when the NIC grade variation was ≥1. Presence of thrombus was also investigated. Distribution of dominant NIC grade (CoCr-EES: grade 0, 9%; grade 1, 77%; grade 2, 9%; grade 3, 5%; R-ZES: grade 0, 16%; grade 1: 47%; grade 2, 37%; grade 3, 0%, P = 0.38) and heterogeneity of NIC (P = 0.43) were similar between CoCr-EES and R-ZES groups. Existence of thrombus was not significantly different in CoCr-EES and R-ZES (18 versus 42%, P = 0.17). Arterial repair occurred without significant differences between CoCr-EES and R-ZES 4 months after implantation.

Keywords

Angioscopy Arterial repair Drug-eluting stent 
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Notes

Acknowledgements

We acknowledge the expertise of Drs. Shota Okuno, Yasuhiro Matsuda and Koji Yanaka in performing cardiac catheterization.

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest to declare.

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Copyright information

© Japanese Association of Cardiovascular Intervention and Therapeutics 2017

Authors and Affiliations

  • Takayuki Ishihara
    • 1
  • Osamu Iida
    • 1
  • Masashi Fujita
    • 1
  • Masaharu Masuda
    • 1
  • Shin Okamoto
    • 1
  • Kiyonori Nanto
    • 1
  • Takashi Kanda
    • 1
  • Takuya Tsujimura
    • 1
  • Akihiro Sunaga
    • 1
  • Masaki Awata
    • 2
  • Shinsuke Nanto
    • 3
  • Masaaki Uematsu
    • 1
  1. 1.Cardiovascular Center, Kansai Rosai HospitalAmagasakiJapan
  2. 2.Department of Cardiovascular MedicineOsaka University Graduate School of MedicineSuitaJapan
  3. 3.Nishinomiya Municipal Central HospitalNishinomiyaJapan

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