Plastic Changes in the White Matter Induced by Templestay, a 4-Day Intensive Mindfulness Meditation Program
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Further explorations are needed to determine how behavioral-lifestyle changes of various types influence neural plasticity in the white matter (WM); in particular, little is known about the influence of one’s self-discipline on changes in WM. A retreat program called Templestay follows the self-discipline practices used by Buddhist monks for 3 nights and 4 days; this program mainly involves meditation and other forms of behavioral-lifestyle modifications. In this study, we explored how neural plasticity occurs in WM structures in response to a relatively short retreat program.
We designed a longitudinal study that investigates WM neural plasticity over the course of Templestay. The Templestay group experienced the daily life of Buddhist practitioners, whereas the control group only participated in a retreat program at the same temple. Diffusion tensor imaging data were acquired before and after the Templestay program to investigate neural plasticity in the WM. We examined changes in the fractional anisotropy maps.
We observed significant changes in the fractional anisotropy maps at the left superior longitudinal fasciculus, left posterior corona radiata, and splenium of the corpus callosum after 4 days of Templestay. Based on the results of our study, a 4-day meditation period in combination with behavioral-lifestyle modifications facilitates WM myelination in regions important for cognitive functions.
These results provide evidence of very rapid structural remodeling of the WM, suggesting that activity-dependent changes in myelination are induced by Templestay, a relatively understudied self-discipline program that includes behavioral-lifestyle modifications.
KeywordsMindfulness training Meditation Neural plasticity Templestay Diffusion tensor imaging Fractional anisotropy
Data Availability Statement
All data are available at the Open Science Framework (https://osf.io/2x5wg/).
YBY and DB: analyzed the data and wrote the manuscript. SK, WJH, and KKC: acquired the MRI data. TYL and SNK: collaborated in recruitment and study procedures. KYL and HYP: participated in theoretical development. JSK: collaborated in the writing and editing of the final manuscript. YBY and DB contributed equally to this work. All authors approved the final version of the manuscript for submission.
This study was supported by the Brain Research Program through the National Research Foundation of Korea, funded by the Ministry of Science, ICT and Future Planning (Grant No. 2017M3C7A1029610; Grant No. 2016R1E1A1A02921618).
Compliance with Ethical Standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The present study was approved by the Institutional Review Board of Seoul National University Hospital.
Informed consent was obtained from all individual participants included in the study.
Conflict of interest
The authors declare that they have no conflict of interest.
- Bloss, E. B., Janssen, W. G., Ohm, D. T., Yuk, F. J., Wadsworth, S., Saardi, K. M., et al. (2011). Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex. The Journal of Neuroscience, 31(21), 7831–7839. https://doi.org/10.1523/JNEUROSCI.0839-11.2011.CrossRefPubMedPubMedCentralGoogle Scholar
- Chetelat, G., Mezenge, F., Tomadesso, C., Landeau, B., Arenaza-Urquijo, E., Rauchs, G., et al. (2017). Reduced age-associated brain changes in expert meditators: a multimodal neuroimaging pilot study. Scientific Reports, 7(1), 10160. https://doi.org/10.1038/s41598-017-07764-x.CrossRefPubMedPubMedCentralGoogle Scholar
- Cho, K. I., Shenton, M. E., Kubicki, M., Jung, W. H., Lee, T. Y., Yun, J. Y., et al. (2016). Altered thalamo-cortical white matter connectivity: probabilistic tractography study in clinical-high risk for psychosis and first-episode psychosis. Schizophrenia Bulletin, 42(3), 723–731. https://doi.org/10.1093/schbul/sbv169.CrossRefPubMedGoogle Scholar
- Cho, K. I. K., Kim, M., Yoon, Y. B., Lee, J., Lee, T. Y., & Kwon, J. S. (2019). Disturbed thalamocortical connectivity in unaffected relatives of schizophrenia patients with a high genetic loading. Australian and New Zealand Journal of Psychiatry, 6, 4867418824020. https://doi.org/10.1177/0004867418824020.CrossRefGoogle Scholar
- Chourbaji, S., Brandwein, C., & Gass, P. (2011). Altering BDNF expression by genetics and/or environment: impact for emotional and depression-like behaviour in laboratory mice. Neuroscience and Biobehavioral Reviews, 35(3), 599–611. https://doi.org/10.1016/j.neubiorev.2010.07.003.CrossRefPubMedGoogle Scholar
- Engvig, A., Fjell, A. M., Westlye, L. T., Moberget, T., Sundseth, O., Larsen, V. A., et al. (2012). Memory training impacts short-term changes in aging white matter: a longitudinal diffusion tensor imaging study. Human Brain Mapping, 33(10), 2390–2406. https://doi.org/10.1002/hbm.21370.CrossRefPubMedGoogle Scholar
- Fox, K., Nijeboer, S., Dixon, M. L., Floman, J. L., Ellamil, M., Rumak, S. P., et al. (2014). Is meditation associated with altered brain structure? A systematic review and meta-analysis of morphometric neuroimaging in meditation practitioners. Neuroscience and Biobehavioral Reviews, 43, 48–73. https://doi.org/10.1016/j.neubiorev.2014.03.016.CrossRefPubMedGoogle Scholar
- Hwang, W. J., Lee, T. Y., Lim, K. O., Bae, D., Kwak, S., Park, H. Y., et al. (2018). The effects of four days of intensive mindfulness meditation training (Templestay program) on resilience to stress: a randomized controlled trial. Psychology, Health & Medicine, 23(5), 497-504. https://doi.org/10.1080/13548506.2017.1363400.CrossRefGoogle Scholar
- Kang, D.-H., Jo, H. J., Jung, W. H., Kim, S. H., Jung, Y.-H., Choi, C.-H., et al. (2013). The effect of meditation on brain structure: cortical thickness mapping and diffusion tensor imaging. Social Cognitive and Affective Neuroscience, 8(1), 27–33. https://doi.org/10.1093/scan/nss056.CrossRefPubMedGoogle Scholar
- Makris, N., Kennedy, D. N., McInerney, S., Sorensen, A. G., Wang, R., Caviness, V. S., Jr., et al. (2005). Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study. Cerebral Cortex, 15(6), 854–869. https://doi.org/10.1093/cercor/bhh186.CrossRefPubMedGoogle Scholar
- Mori, S., Wakana, S., Van Zijl, P. C., & Nagae-Poetscher, L. (2005). MRI atlas of human white matter. Amsterdam: ElsevierGoogle Scholar
- Sampaio-Baptista, C., Khrapitchev, A. A., Foxley, S., Schlagheck, T., Scholz, J., Jbabdi, S., et al. (2013). Motor skill learning induces changes in white matter microstructure and myelination. The Journal of Neuroscience, 33(50), 19499–19503. https://doi.org/10.1523/JNEUROSCI.3048-13.2013.CrossRefPubMedPubMedCentralGoogle Scholar
- Stadlbauer, A., Salomonowitz, E., Strunk, G., Hammen, T., & Ganslandt, O. (2008). Age-related degradation in the central nervous system: assessment with diffusion-tensor imaging and quantitative fiber tracking. Radiology, 247(1), 179–188. https://doi.org/10.1148/radiol.2471070707.CrossRefPubMedGoogle Scholar
- Tang, Y. Y., Ma, Y., Fan, Y., Feng, H., Wang, J., Feng, S., et al. (2009). Central and autonomic nervous system interaction is altered by short-term meditation. Proceedings of the National Academy of Sciences of the United States of America, 106(22), 8865–8870. https://doi.org/10.1073/pnas.0904031106.CrossRefPubMedPubMedCentralGoogle Scholar
- Tang, Y. Y., Yang, L., Leve, L. D., & Harold, G. T. (2012b). Improving executive function and its neurobiological mechanisms through a mindfulness-based intervention: advances within the field of developmental neuroscience. Child Development Perspectives, 6(4), 361–366. https://doi.org/10.1111/j.1750-8606.2012.00250.x.CrossRefPubMedPubMedCentralGoogle Scholar
- Taylor, P. N., & Forsyth, R. (2016). Heterogeneity of trans-callosal structural connectivity and effects on resting state subnetwork integrity may underlie both wanted and unwanted effects of therapeutic corpus callostomy. NeuroImage: Clinical, 12, 341–347. https://doi.org/10.1016/j.nicl.2016.07.010.CrossRefGoogle Scholar
- Yoon, Y. B., Yun, J. Y., Jung, W. H., Cho, K. I. K., Kim, S. N., Lee, T. Y., et al. (2015). Altered Fronto-temporal functional connectivity in individuals at ultra-high-risk of developing psychosis. PLoS One, 10(8), e0135347. https://doi.org/10.1371/journal.pone.0135347.CrossRefPubMedPubMedCentralGoogle Scholar
- Yoon, Y. B., Kim, M., Lee, J., Cho, K. I. K., Kwak, S., Lee, T. Y., & Kwon, J. S. (2019). Effect of tDCS on aberrant functional network connectivity in refractory hallucinatory schizophrenia: a pilot study. Psychiatry Investigation, 16(3), 244–248. https://doi.org/10.30773/pi.2018.11.18.CrossRefPubMedPubMedCentralGoogle Scholar
- Zarei, M., Johansen-Berg, H., Smith, S., Ciccarelli, O., Thompson, A. J., & Matthews, P. M. (2006). Functional anatomy of interhemispheric cortical connections in the human brain. Journal of Anatomy, 209(3), 311–320. https://doi.org/10.1111/j.1469-7580.2006.00615.x.CrossRefPubMedPubMedCentralGoogle Scholar