Advertisement

Screening Assessment of Renal Function Status in Healthy Smoking Volunteers

  • Sayar R. Abdulkhakov
  • Evgenii V. ArkhipovEmail author
  • Rashat I. Faizullin
  • Irina V. Sidorova
  • Alina A. Ibragimova
  • Leila R. Gaysina
  • Julia V. Oslopova
  • Ekaterina Ju. Pronina
  • Dilyara D. Safina
  • Ildaria Kh. Valeeva
  • Vadim A. Salomatin
  • Evgeniya V. Gnuchikh
  • Evgeniya E. Arinina
  • Andrey P. Kiassov
Article
  • 1 Downloads

Abstract

The study objective was to evaluate the renal function status in overall healthy smokers. Renal function status was studied in 61 apparently healthy smokers aged 21–64 years (49 males and 12 females). The evaluation included taking a history with the smoking status assessment, a physical examination with assessment of systolic and diastolic blood pressure, blood and urine biochemistry, and calculation of glomerular filtration rate (GFR; CKD-EPI, 2009). The period of observation lasted for 7 days. High blood pressure and obesity had no impact on the kidney function (p > 0.05). Healthy smoking volunteers initially had a high GFR and a “high-normal” urine albumin level as compared to the group of healthy non-smokers (р = 0.000 and р = 0.012, respectively). The risk analysis showed that smoking increased 11-fold the risk of hyperfiltration (RR = 11.1, CI 95% 1.57–76.51, p = 0.001) and 5-fold the occurrence of albuminuria (RR = 5.1, CI 95% 0.71–36.99, p = 0.009) in smokers without initial renal pathology as compared to never-smokers. Those who abstained from smoking showed a moderate decrease of albuminuria (p = 0.049). Systematic tobacco consumption contributes to the development of a renal dysfunction with the occurrence of albuminuria and hyperfiltration (GFR ≥ 125 ml/min/1.73 m2). Timely smoking cessation promotes the regression of albuminuria.

Keywords

Kidney Smoking Renal function Albuminuria 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Глобальный опрос взрослого населения о потреблении табака. (Global Adult Tobacco Survey – GATS, 2009) Russian Federation, 2009. Accessed May 23, 2018. Available at: http://www.who.int/tobacco/surveillance/ru_tfi_gatsrussian_countryreport.pdf
  2. 2.
    Investing in health research and development. Report of the Ad Hoc Committee on Health Research Relating to Future Intervention Options. The World Health Organization, Geneva, Switzer-land. 1996; Accessed May 23, 2018. Available at: http://www.who.int/tdr/publications/documents/investing.pdf
  3. 3.
    Hammond, E. C., & Horn, D. (1958). Smoking and death rates: report of forty-four months of follow-up of 187 783 men. II. Death rates by cause. Journal of the American Medical Association, 166(11), 1294–1308.  https://doi.org/10.1001/jama.1958.02990110030007.CrossRefGoogle Scholar
  4. 4.
    Auerbach, O., Hammond, E. C., & Garfinkel, L. (1965). Smoking in relation to atherosclerosis of the coronary arteries. The New England Journal of Medicine, 273, 775–779.  https://doi.org/10.1056/nejm196510072731501.CrossRefGoogle Scholar
  5. 5.
    Sherman, C. B. (1992). The health consequences of cigarette smoking: pulmonary diseases. The Medical Clinics of North America, 76, 3550375.CrossRefGoogle Scholar
  6. 6.
    Orth, S. R., Ogata, H., & Ritz, E. (2000). Smoking and the kidney. Nephrology, Dialysis, Transplantation, 15(10), 1509–1511.  https://doi.org/10.1093/ndt15/10/1509.CrossRefGoogle Scholar
  7. 7.
    K/DOQI: Clinical practical guidelines for chronic kidney disease: evaluation, classification and stratification. Accessed May 23, 2018. Available at: http://kdigo.org/wp-content/uploads/2017/02/Russian_KDIGO-CKD-Guideline.pdf
  8. 8.
    Orth, S. R. (2002). Cigarette smoking: an important renal risk factor – far beyond carcinogenesis. Tobacco Induced Diseases., 1(2), 137–155.  https://doi.org/10.1186/1617-9625-1-2-137.CrossRefGoogle Scholar
  9. 9.
    Pinto-Sietsma, S. J., Mulder, J., Janssen, W. M., Hillege, H. L., de Zeeuw, D., & de Jong, P. E. (2000). Smoking is related to albuminuria and abnormal renal function in nondiabetic persons. Annals of Internal Medicine, 133(8), 585–591.  https://doi.org/10.7326/0003-4819-133-8-200010170-00008.CrossRefGoogle Scholar
  10. 10.
    Ishizaka, N., Ishizaka, Y., Toda, E., Shimomura, H., Koike, K., Seki, G., Nagai, R., & Yamakado, M. (2008). Association between cigarette smoking and chronic kidney disease in Japanese men. Hypertension Research, 31(3), 485–492.  https://doi.org/10.1291/hypres.31.485.CrossRefGoogle Scholar
  11. 11.
    Franceschini, N., Deng, Y., Flessner, M. F., Eckfeldt, J. H., Kramer, H. J., Lash, J. P., & Cai, J. (2016). Smoking patterns and chronic kidney disease in US Hispanics: Hispanic community health study/study of Latinos. Nephrology, Dialysis, Transplantation, 31(10), 1670–1676.  https://doi.org/10.1093/ndt/gfw210.CrossRefGoogle Scholar
  12. 12.
    Appel, R. G., Bleyer, A. J., Reavis, S., & Hansen, K. J. (1995). Renovascular disease in older patients beginning renal replacement therapy. Kidney International, 48, 171–176.  https://doi.org/10.1038/ki.1995.281.CrossRefGoogle Scholar
  13. 13.
    Oberai, B., Adams, C. W. M., & High, O. B. (1984). Myocardial and renal arteriolar thickening in cigarette smoking. Atherosclerosis, 52, 185–190.  https://doi.org/10.1016/0021-9150(84)90116-3.CrossRefGoogle Scholar
  14. 14.
    Yacoub, R., Habib, H., Lahdo, A., Ali, R. A., Varjabedian, L., Atalla, G., Akl, N. K., Aldakheel, S., Alahdab, S., & Albitar, S. (2010). Association between smoking and chronic kidney disease: a case control study. BMC Public Health, 10, 731.  https://doi.org/10.1186/1471-2458-10-731.CrossRefGoogle Scholar
  15. 15.
    Jain, G., & Jaimes, E. A. (2013). Nicotine signaling and progression of chronic kidney disease in smokers. Biochemical Pharmacology, 86(8), 1215–1223.  https://doi.org/10.1016/j.bcp.2013.07.014.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Sayar R. Abdulkhakov
    • 1
    • 2
  • Evgenii V. Arkhipov
    • 2
    Email author
  • Rashat I. Faizullin
    • 1
  • Irina V. Sidorova
    • 1
  • Alina A. Ibragimova
    • 1
  • Leila R. Gaysina
    • 1
  • Julia V. Oslopova
    • 1
  • Ekaterina Ju. Pronina
    • 1
  • Dilyara D. Safina
    • 1
  • Ildaria Kh. Valeeva
    • 2
  • Vadim A. Salomatin
    • 3
  • Evgeniya V. Gnuchikh
    • 3
  • Evgeniya E. Arinina
    • 4
  • Andrey P. Kiassov
    • 1
  1. 1.Kazan (Volga Region) Federal UniversityKazanRussia
  2. 2.Kazan State Medical University of the Ministry of Healthcare of the Russian FederationKazanRussia
  3. 3.Federal State Budget Scientific Institution All-Russian Scientific Research Institute of Tobacco, Makhorka and Tobacco ProductsKrasnodarRussia
  4. 4.Federal Scientific State Budgetary Institution “N.A. Semashko National Research Institute of Public Health”MoscowRussia

Personalised recommendations