Influence of Cross-linking Agents on Drug Delivery Behavior of Magnetic Nanohydrogels Made of Polyvinyl Alcohol and Chitosan

  • Hamidreza ShagholaniEmail author
  • Sayed Mehdi Ghoreishi
  • Reza Rahmatolahzadeh


With the purpose of examining cross-linking agents, we used glutaraldehyde and ammonium persulfate to synthesize nanohydrogels based on poly(vinyl alcohol), chitosan, and magnetite nanoparticles. Fe3O4 nanoparticles were produced by coprecipitation in alkaline solution under sonication followed by coating with chitosan. Then, poly(vinyl alcohol) was combined with chitosan in the presence of glutaraldehyde and ammonium persulfate as cross-linking agents. The Fe3O4 nanoparticles had nanoscale size that was confirmed by XRD, SEM, and TEM. VSM measurements showed that all samples were superparamagnetic. Physicochemical properties of nanohydrogels were measured by DLS and zeta potential. The unspecific adsorption and interaction of nanohydrogels with bovine serum albumin and immunoglobulin G were investigated systematically by UV-Vis spectroscopy method. The release profile of nanohydrogels showed that nanohydrogels cross-linked with glutaraldehyde represent more sensitivity to pH. These nanohydrogels had more and faster release in acidic release medium.


Fe3O4 nanoparticles Chitosan Poly(vinyl alcohol) Drug delivery Cross-linking agent 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Research Involving Humans and Animals Statement


Informed Consent


Funding Information

There are no sources of financial funding and support.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Hamidreza Shagholani
    • 1
    Email author
  • Sayed Mehdi Ghoreishi
    • 2
  • Reza Rahmatolahzadeh
    • 3
  1. 1.Institute of Nanoscience and NanotechnologyUniversity of KashanKashanIran
  2. 2.Department of Analytical Chemistry, Faculty of ChemistryUniversity of KashanKashanIran
  3. 3.Tehran Firefighting Center of Applied Science and TechnologyTehranIran

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