Novel Solid Dispersions Increasing the Solubility of Prothionamide
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Water solubility of prothionamide and its solid dispersions with polyethylene glycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin was studied. The most promising results were obtained with the solid dispersion with polyvinylpyrrolidone, which provided a 2.6-fold general increase of drug’s solubility and about a 6-fold dissolution rate increase, the maximal values among the studied drug forms. The results of complex physicochemical studies suggested that the improved drug release was due to micronization and solubilizing action of the polymer. A principal factor was the destruction of the crystal lattice and formation of amorphous particles in the solid dispersion. The obtained data can be useful for the development of modified pharmaceutical forms of prothionamide with improved drug release profile.
KeywordsProthionamide Solid dispersions Polyethyleneglycol-1500 (PEG) Polyvinylpyrrolidone-10000 (PVP) β-Cyclodextrin Solubility
The work is performed according to the Russian Government Program of Competitive Growth of I.M. Sechenov First Moscow State University and Kazan Federal University.
Compliance with Ethical Standards
Conflict of Interest
Research Involving Humans and Animals Statement
Research were conducted “in vitro” without involving humans and animals.
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