Investigation of Asymmetric Dimethylarginine, Adiponectin, Zn, and Cu Levels in Obese Subjects
- 53 Downloads
Obesity plays a role in the pathogenesis of various diseases such as especially inflammatory process and metabolic syndrome. Herein, we aimed to determine levels of adiponectin, asymmetric dimethylarginine, zinc, and copper in obese as well as the evaluation of the relationship among them because we could not find any study evaluated together that these parameters affected by each other in the same patient group. The white adipose tissue is considered to be the most significant energy reservoir and secretes a large number of biologically active adipokines. Adiponectin from these adipokines draws attention due to antidiabetic and antiatherogenic effects and is expected to be a new therapeutic tool for diabetes and metabolic syndrome. Individuals were created obese and control subjects. Obese individuals were identified by body mass index (BMI). Adiponectin levels in serum were measured by ELISA test, asymmetric dimethylarginine was analyzed by using HPLC method, and Cu and Zn levels were determined with the help of absorption spectroscopy. Adiponectin was significantly lower (p < 0.001) in obese subjects whereas copper was significantly higher (p < 0.001) compared to the control group. However, no statistical differences were observed between asymmetric dimethylarginine and Zn levels. Besides, adiponectin amounts were inversely related to copper and BMI. Furthermore, there was a positive correlation between copper and BMI in the subjects. Our findings have shown a significant relation between adiponectin and Cu levels in obese subjects. Also, adiponectin has an essential role in the etiopathogenesis of obesity and adiponectin administration, and Cu restriction might be important in the issue of obesity.
KeywordsAsymmetric dimethylarginine Adiponectin Obesity
Compliance with ethical standards
The experimental protocol was approved by the Selçuk Universty Meram Medical Fakulty ethics committee, Konya, Turkey, under permit No. 2009/098, and all subjects were informed about the this study, and written consent of each patient was received.
- 1.Mehmetoğlu, I., Gökce, S., Kurban, S., Gökce, R., Atalar, M. N., & Celik, M. (2017). Publication investigation of the relationships of obesity with melatonin and dehydroepiandrosterone levels. Journal of Chromatography B and Nobel Medicus, 13(2), 70–75.Google Scholar
- 2.WHO Obesity: Preventing and managing the global epidemic. Technical Report Series number 894, (2000), WHO, Geneva.Google Scholar
- 3.Egger, G., & Dixon, J. (2014). Beyond obesity and lifestyle: a review of 21st century chronic disease determinants. BioMed Research International, 2014. https://doi.org/10.1155/2014/731685.
- 4.Mela, D., (Ed.) (2005) Food, diet and obesity, Elsevier, e-Book ISBN: 9781845690540.Google Scholar
- 5.Abarca-Gómez, L., Abdeen, Z. A., Hamid, Z. A., Abu-Rmeileh, N. M., Acosta-Cazares, B., Acuin, C., et al. (2017). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128· 9 million children, adolescents, and adults. The Lancet, 390(10113), 2627–2642.CrossRefGoogle Scholar
- 6.Pietro, D., Oliver, R. (2016) Methods for weight loss and ketogenic compositions, U.S. Patent No 9, 370–553.Google Scholar
- 7.Knight, J. A. (2011). Diseases and disorders associated with excess body weight. Annals of Clinical & Laboratory Science, 41(2), 107–121.Google Scholar
- 8.Bjorntorp, P. (2001) International textbook of obesity, John Wıley and Sons Ltd., pp. 305–314.Google Scholar
- 15.Hooper, N.M. (2014) The biological roles of zinc and families of zinc metalloproteases. In Zinc metalloproteases in health and disease, CRC Press, pp. 21–42.Google Scholar
- 16.Shah, O.S., Baba, A.R., Dar, Z.A., Hussain, T., Amin, U., Jan, A., et al. (2017) Zinc as an element of therapeutic importance: A review. environment, 6 (12), pp. 433–436.Google Scholar
- 31.Nigro, E. et al.(2014) New insight into adiponectin role in obesity and obesity-related diseases, BioMed Research International.Google Scholar
- 41.Ahmed, N., Shah, N. A., Ahmad, B., Shah, S. I. A., Ulhaq, S., Rahimi-Gorji, M., et al. Journal of Applied and Computational Mechanics. https://doi.org/10.22055/JACM.2018.26947.1364.
- 43.Rahimi-Gorji, M., Ghajar, M., Kakaee, A.-H., & Ganji, D. D. (2017). Modeling of the air conditions effects on the power and fuel consumption of the SI engine using neural networks and regression. Journal of the Brazilian Society of Mechanical Sciences and Engineering, 39(2), 375–384.CrossRefGoogle Scholar
- 50.Günbatar, S., Aygun, A., Karatas, Y., Gülcan, M., & Sen, F. Carbon-nanotube-based rhodium nanoparticles as highly-active catalyst for hydrolytic dehydrogenation of dimethylamineborane at room temperature. Journal of Colloid and Interface Science, 530, 321–327.Google Scholar
- 52.Ayranci, R., Baskaya, G., Guzel, M., Bozkurt, S., Ak, M., Savk, A., & Sen, F. (2017). Carbon based nanomaterials for high performance optoelectrochemical systems. Chemistry Select, 2(4), 1548–1555.Google Scholar
- 53.Rahimi-Gorji, M., Pourmehran, O., Gorji-Bandpy, M., & Ganji, D. D. (2016). Unsteady squeezing nanofluid simulation and investigation of its effect on important heat transfer parameters in presence of magnetic field. Journal of the Taiwan Institute of Chemical Engineers, 67, 467–475.CrossRefGoogle Scholar
- 55.Mosayebidorcheh, S., Rahimi-Gorji, M., Ganji, D. D., Moayebidorcheh, T., Pourmehran, O., & Biglarian, M. (2017). Transient thermal behavior of radial fins of rectangular, triangular and hyperbolic profiles with temperature-dependent properties using DTM-FDM. Journal of Central South University, 24(3), 675–682.CrossRefGoogle Scholar
- 57.Pourmehran, O., Rahimi-Gorji, M., Gorji-Bandpy, M., & Gorji, T. B. (2015). Simulation of magnetic drug targeting through tracheobronchial airways in the presence of an external non-uniform magnetic field using Lagrangian magnetic particle tracking. Journal of Magnetism and Magnetic Materials, 393, 380–393.CrossRefGoogle Scholar