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BioNanoScience

, Volume 8, Issue 3, pp 944–949 | Cite as

Immunologic Parallels: Infectious Burden and Markers of Atopic Response Type

  • Elena V. AgafonovaEmail author
  • Lidiia V. Krestnikova
  • Alexandra V. Salmakova
  • Guzel Sh. Isaeva
  • Elvira V. Syrykh
Article
  • 38 Downloads

Abstract

The relationship between serological markers of infections and the atopic status of patients with allergy symptoms (rhinorrhea, nasal congestion, recurrent cough, asthma attacks, recurrent skin rashes combined with skin itching) and an increased total Ig E level was investigated. The determination of an infectious burden included screening for bacterial pathogens, protozoa, and helminths. All patients also had specific—food and inhalation—Ig E testing done. The relationship between the infectious burden and a specific atopic status is ambiguous—different pathogens have different types of effects such as opposite, synergistic, or no effect in mono-exposure. In addition, it has been shown that the pattern of pathogen influence on specific IgE response can vary in different age periods. This is due to both cumulative effects associated with a prolonged antigen burden and “switching” of the immune response that forms a hyperimmune IgE response as a protective phenomenon against helminths.

Keywords

Infectious burden Pathogens Specific Ig E Immunology 

Notes

Funding Information

The work was partially supported by the Russian Government Program of Competitive Growth of the Kazan Federal University and a subsidy allocated to the Kazan Federal University for the state assignment in the sphere of scientific activities. Some of the experiments were conducted using the equipment of the Interdisciplinary center for collective use of the Kazan Federal University supported by the Ministry of Education of Russia and the Pharmaceutical Research and Education Center, Kazan (Volga Region) Federal University, Kazan, Russia.

Compliance with Ethical Standards

The study was approved by the Bioethics Committee at the Kazan Research Institute of Epidemiology and Microbiology (the minutes No. 31 dated on 02.12.2016).

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Elena V. Agafonova
    • 1
    • 2
    Email author
  • Lidiia V. Krestnikova
    • 2
    • 3
  • Alexandra V. Salmakova
    • 4
  • Guzel Sh. Isaeva
    • 1
    • 2
  • Elvira V. Syrykh
    • 2
  1. 1.Kazan State Medical UniversityKazanRussia
  2. 2.Kazan Research Institute of Epidemiology and MicrobiologyKazanRussia
  3. 3.Hygiene and Epidemiology Centre in the Republic of TatarstanKazanRussia
  4. 4.Kazan Federal UniversityKazanRussia

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