, Volume 8, Issue 3, pp 944–949 | Cite as

Immunologic Parallels: Infectious Burden and Markers of Atopic Response Type

  • Elena V. AgafonovaEmail author
  • Lidiia V. Krestnikova
  • Alexandra V. Salmakova
  • Guzel Sh. Isaeva
  • Elvira V. Syrykh


The relationship between serological markers of infections and the atopic status of patients with allergy symptoms (rhinorrhea, nasal congestion, recurrent cough, asthma attacks, recurrent skin rashes combined with skin itching) and an increased total Ig E level was investigated. The determination of an infectious burden included screening for bacterial pathogens, protozoa, and helminths. All patients also had specific—food and inhalation—Ig E testing done. The relationship between the infectious burden and a specific atopic status is ambiguous—different pathogens have different types of effects such as opposite, synergistic, or no effect in mono-exposure. In addition, it has been shown that the pattern of pathogen influence on specific IgE response can vary in different age periods. This is due to both cumulative effects associated with a prolonged antigen burden and “switching” of the immune response that forms a hyperimmune IgE response as a protective phenomenon against helminths.


Infectious burden Pathogens Specific Ig E Immunology 


Funding Information

The work was partially supported by the Russian Government Program of Competitive Growth of the Kazan Federal University and a subsidy allocated to the Kazan Federal University for the state assignment in the sphere of scientific activities. Some of the experiments were conducted using the equipment of the Interdisciplinary center for collective use of the Kazan Federal University supported by the Ministry of Education of Russia and the Pharmaceutical Research and Education Center, Kazan (Volga Region) Federal University, Kazan, Russia.

Compliance with Ethical Standards

The study was approved by the Bioethics Committee at the Kazan Research Institute of Epidemiology and Microbiology (the minutes No. 31 dated on 02.12.2016).

Conflict of Interest

The authors declare that they have no conflict of interest.


  1. 1.
    Cruz, A. A., Cooper, P. J., Figueiredo, C. A., Alcantara-Neves, N. M., Rodrigues, L. C., & Barreto, M. L. (2017). Global issues in allergy and immunology: Parasitic infections and allergy. The Journal of Allergy and Clinical Immunology, 140(5), 1217–1228.CrossRefGoogle Scholar
  2. 2.
    Arnold, I. C., Hitzler, I., & Müller, A. (2012). The immunomodulatory properties of Helicobacter pylori confer protection against allergic and chronic inflammatory disorders. Frontiers in Cellular and Infection Microbiology, 2(10), 3389–3330.Google Scholar
  3. 3.
    Taye, B., Enquselassie, F., Amberbir, A., Medhin, G., Fogarty, A., Robinson, K., & Davey, G. (2017). Association between infection with Helicobacter pylori and atopy in young Ethiopian children: A longitudinal study. Clinical and Experimental Allergy, 47(10), 1299–1308.CrossRefGoogle Scholar
  4. 4.
    Alcantara-Neves, N. M., Veiga, R. V., Dattoli, V. C., Fiaccone, R. L., Esquivel, R., Cruz, Á. A., Cooper, P. J., Rodrigues, L. C., & Barreto, M. L. (2012). The effect of single and multiple infections on atopy and wheezing in children. The Journal of Allergy and Clinical Immunology, 129, 359–367.CrossRefGoogle Scholar
  5. 5.
    Wang, Y. C., Lin, T. Y., Shang, S. T., Chen, H. J., Kao, C. H., Wu, C. C., & Yang, T. Y. (2017). Helicobacter pylori infection increases the risk of adult-onset asthma: a nationwide cohort study. European Journal of Clinical Microbiology & Infectious Diseases, 36(9), 1587–1594.CrossRefGoogle Scholar
  6. 6.
    Figura, N., Perrone, A., Gennari, C., Orlandini, G., Giannace, R., Lenzi, C., Vagliasindi, M., Bianciardi, L., & Rottoli, P. (2009). CagA-positive Helicobacter pylori infection may increase the risk of food allergy development. Journal of Physiology and Pharmacology, 50, 827–831.Google Scholar
  7. 7.
    Ma, Z. F., Majid, N. A., Yamaoka, Y., & Lee, Y. Y. (2016). Food allergy and helicobacter pylori infection: a systematic review. Frontiers in Microbiology, 23(7), 368.Google Scholar
  8. 8.
    van Wijck, Y., de Kleijn, S., John-Schuster, G., TCJ, M., Hiemstra, P. S., Müller, A., Smits, H. H., & Taube, C. (2018). Therapeutic application of an extract of Helicobacter pylori ameliorates the development of allergic airway disease. Journal of Immunology, 200(5), 1570–1579.Google Scholar
  9. 9.
    Costa, R. D., Figueiredo, C. A., Barreto, M. L., Alcantara-Neves, N. M., Rodrigues, L. C., Cruz, A. A., Vergara, C., Rafaels, N., Foster, C., Potee, J., Campbell, M., Mathias, R. A., & Barnes, K. C. (2017). Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population. Annals of Allergy, Asthma & Immunology, 118(4), 483–488.CrossRefGoogle Scholar
  10. 10.
    Matricardi, P. M., Rosmini, F., Riondino, S., Fortini, M., et al. (2000). Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ, 320, 412–417.CrossRefGoogle Scholar
  11. 11.
    Belmer SV Giardiasis in children (2004) Pediatric Gastroenterology and Nutriciology. 12(3): P.141–143 (In Rus).Google Scholar
  12. 12.
    Agafonova, E. V., YuA, T., Dolbin, D. A., & Kulikov, S. N. (2008). Modern aspects of diagnosis of giardiasis in humans. Russian Medical Journal, 17, 112011 (In Rus).Google Scholar
  13. 13.
    Daschner, A., & Pascual, C. Y. (2005). Anisakis simplex: Sensitization and clinical allergy. Current Opinion in Allergy and Clinical Immunology, 5(3), 281–285.CrossRefGoogle Scholar
  14. 14.
    Pritchard, D. I., Shakib, F., Walsh, E. A., & Smith, S. J. (2013). Measurement of hookworm infection intensity and circulation levels of IgE and antybodies to IgE in atopics and nonatopic living in a parasitized community in Papua New Guinea. Journal of Investigational Allergology & Clinical Immunology, 4(5), 238–241.Google Scholar
  15. 15.
    Hagel, I., Lynch, N. R., & Perez, M. Р. (2003). Modulation of the allergic reactivity of slum children by helminthic infection. Parasite Immunology, 15(6), 311–315.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Elena V. Agafonova
    • 1
    • 2
    Email author
  • Lidiia V. Krestnikova
    • 2
    • 3
  • Alexandra V. Salmakova
    • 4
  • Guzel Sh. Isaeva
    • 1
    • 2
  • Elvira V. Syrykh
    • 2
  1. 1.Kazan State Medical UniversityKazanRussia
  2. 2.Kazan Research Institute of Epidemiology and MicrobiologyKazanRussia
  3. 3.Hygiene and Epidemiology Centre in the Republic of TatarstanKazanRussia
  4. 4.Kazan Federal UniversityKazanRussia

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