BioNanoScience

, Volume 8, Issue 1, pp 454–458 | Cite as

Capabilities of Molecular-Based Allergen Diagnostics in Atopic Diseases

  • Irina Reshetnikova
  • Svetlana Khaiboullina
  • Elena Agafonova
Article

Abstract

One hundred thirty-one assays were performed to determine the level of specific IgE to major molecular components of the birch pollen—rBet v 1, timothy grass pollen—rPhl p1, rPhl p 5b, and house dust mites—nDer p1, rDer p2 as well as to the minor components of birch pollen—rBet v 2, rBet v 4, timothy grass pollen—rPhl p7, rPhl p 12, and house dust mites rDer p10 in patients with asthma (N = 66) and allergic rhinitis (N = 65). It is well established that sensitization to major and minor allergens facilitates the selection of an allergen for the allergen-specific immunotherapy (ASIT). According to the concept of molecular-based allergen diagnostics, the ASIT efficacy is expected to be high when IgЕ to major components are present and antibodies to minor components are absent. When elevated IgЕ levels to major and minor ASIT proteins are present, a moderate ASIT efficacy is expected.

Keywords

Molecular-based allergen diagnostics Major allergen Minor allergen Allergen-specific immunotherapy 

Notes

Acknowledgements

The work was partially supported by the Russian Government Program of Competitive Growth of the Kazan Federal University.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Irina Reshetnikova
    • 1
    • 2
  • Svetlana Khaiboullina
    • 2
    • 3
  • Elena Agafonova
    • 1
    • 4
  1. 1.Kazan Scientific-Research Institute of Epidemiology and MicrobiologyKazanRussia
  2. 2.Kazan Federal UniversityKazanRussia
  3. 3.University of NevadaRenoUSA
  4. 4.Kazan State Medical UniversityKazanRussia

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