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A prospective study on incidence, risk factors, and validation of a risk score for post-infection irritable bowel syndrome in coastal eastern India

  • Prasanta Kumar Parida
  • Debakanta Mishra
  • Girish Kumar Pati
  • Preetam Nath
  • Kaibalya Ranjan Dash
  • Sambit Kumar Behera
  • Suryakanta Parida
  • Chitta Ranjan Khatua
  • Subhendu Panigrahi
  • Amarendra Mahapatra
  • Hemant Kumar Khuntia
  • Shivaram Prasad SinghEmail author
Original Article

Abstract

Background and Aim

Post-infection irritable bowel syndrome (PI-IBS) can occur following acute gastroenteritis (AGE). This study was designed to evaluate the incidence and risk factors of PI-IBS following AGE and to validate a PI-IBS risk score.

Methods

This prospective study was performed between September 2014 and October 2016 on AGE patients by documenting their AGE severity and following up after 3 and 6 months to study the development of IBS (ROME III criteria). The risk score was calculated for all the subjects, and its discrimination ability was tested.

Results

Out of 136 hospitalized AGE patients, 35 developed PI-IBS after 6 months. The factors associated with PI-IBS were younger age, longer duration of AGE, anxiety, depression, abdominal pain, bloody stool, vomiting, fever, family history of IBS, and positive stool culture (univariate analysis); however, on multivariate analysis, younger age (adjusted odds ratio [AOR] 0.5; p 0.03), prolonged duration of AGE (AOR 8.6; p 0.01), and abdominal cramps (AOR 2.1; p 0.02) were the independent factors influencing its occurrence. PI-IBS occurred even after infection with Vibrio cholerae. The PI-IBS risk score was significantly higher in patients who developed PI-IBS (72.4 ± 14.48 vs. 31.56 ± 20.4, p-value < 0.001); score > 50 had a sensitivity and specificity of 91.4% and 84.2%, respectively.

Conclusion

One fourth of AGE patients developed PI-IBS after 6 months. Factors influencing its development were younger age, long duration of AGE, and abdominal pain. The PI-IBS risk score had good predictive accuracy in our population.

Keywords

Acute gastroenteritis E. coli Irritable bowel syndrome Post-infection irritable bowel syndrome 

Notes

Author contributions

Prasanta Kumar Parida: Collecting data; analysis of data; preparing the initial draft of the manuscript.

Girish Kumar Pati: Preparing the initial draft of the manuscript.

Debakanta Mishra: Analysis of data; preparing the initial draft of the manuscript; critical revision of the manuscript for intellectual content.

Preetam Nath: Study concept and protocol design; analysis of data.

Kaibalya Ranjan Dash: Collecting data; preparing the initial draft of the manuscript.

Sambit Kumar Behera: Critical revision of the manuscript for intellectual content.

Suryakanta Parida: Collecting data; preparing the initial draft of the manuscript.

Chitta Ranjan Khatua: Analysis of data; preparing the initial draft of the manuscript.

Subhendu Panigrahi: Collecting data.

Amarendra Mahapatra: Stool culture and microbiological analysis.

Hemant Kumar Khuntia: Stool culture and microbiological analysis.

Prof. Shivaram Prasad Singh: Study concept and protocol design; study supervision.

Compliance with ethical standards

Conflict of interest

PKP, DM, GKP, PN, KRD, SKB, SP, CRK, SP, AM, HKK, and SPS declare that they have no conflict of interest.

Ethical clearance

The authors declare that the study was performed in a manner conforming to the Helsinki declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown in Springer.com.

Disclaimer

The authors are solely responsible for the data and the content of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, or the printer/publishers are responsible for the results/findings and content of this article.

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Copyright information

© Indian Society of Gastroenterology 2019

Authors and Affiliations

  • Prasanta Kumar Parida
    • 1
  • Debakanta Mishra
    • 1
  • Girish Kumar Pati
    • 2
  • Preetam Nath
    • 3
  • Kaibalya Ranjan Dash
    • 1
  • Sambit Kumar Behera
    • 1
  • Suryakanta Parida
    • 1
  • Chitta Ranjan Khatua
    • 1
  • Subhendu Panigrahi
    • 1
  • Amarendra Mahapatra
    • 4
  • Hemant Kumar Khuntia
    • 4
  • Shivaram Prasad Singh
    • 1
    Email author
  1. 1.Department of GastroenterologyS C B Medical CollegeCuttackIndia
  2. 2.Department of GastroenterologyInstitute of Medical Sciences and SUM HospitalBhubaneswarIndia
  3. 3.Department of GastroenterologyKalinga Institute of Medical ScienceBhubaneswarIndia
  4. 4.Regional Medical Research Centre (RMRC)BhubaneswarIndia

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