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Indian Journal of Gastroenterology

, Volume 38, Issue 1, pp 39–43 | Cite as

Effect of sofosbuvir and daclatasvir on lipid profile, glycemic control and quality of life index in chronic hepatitis C, genotype 3 patients

  • Ayush Jain
  • Bhupinder Singh Kalra
  • Siddharth Srivastava
  • Shalini ChawlaEmail author
Original Article
  • 81 Downloads

Abstract

Objectives

The management of hepatitis C has progressed from interferon-based therapy to oral direct acting antiviral therapy. Deranged lipid levels (total cholesterol, triglyceride) after treatment with interferon-based therapy are well known. There is a paucity of data on changes in lipid profile, glycemic parameters and alteration in quality of life with the newer regimen. This study was designed to assess the changes in lipid profile, glycemic parameters, quality of life in chronic hepatitis C patients with genotype 3 after treatment with sofosbuvir and daclatasvir.

Methods

The study was a single-centre, prospective study, conducted at tertiary care hospital from January 2017 to December 2017. Fifty patients, who received sofosbuvir (400 mg) and daclatasvir (60 mg) orally once daily for a period of 12 weeks for chronic hepatitis C and genotype 3, were recruited.

Results

Total cholesterol levels (166.9 ± 23.8 to 192.4 ± 34.5 mg/dL, p-value < 0.0001) and low-density cholesterol (LDL) levels (100.9 ± 22.8 to 121.6 ± 37.2, p-value < 0.0001) were elevated after the treatment. A significant decrease in median levels of glycated hemoglobin (HbA1c) was observed (5.57% to 5.41%, p-value < 0.002). Quality of life markedly improved in all domains, i.e. physical, physiological, environmental, and social relationships according to an abbreviated form of World Health Organization quality of life assessment named WHOQOL-BREF questionnaire. Treatment was found to be effective with sustained virological response (SVR) achieved in 94% patients.

Conclusions

Our study reports a substantial increment in total cholesterol, and low-density lipoprotein with sofosbuvir and daclatasvir treatment though it achieved SVR in 94% of patients and improved their quality of life.

Keywords

Antiviral therapy Cholesterol Daclatasvir Hepatitis C Quality of life Sofosbuvir 

Notes

Authors contributions

A J: Involved in planning of study, collection, analysis and writing of draft of paper.

S C, B S: Involved in planning of the study, supervision of conduct of study and guided in writing the manuscript.

S S: Helped in clinical supervision of the data collection and review of manuscript.

Funding

None.

Compliance with ethical standards

Conflict of interest

AJ, BSK, SS, and SC declare that they do not have any conflict of interest to report.

Ethical clearance

The authors declare that the study was performed in a manner conforming to the Helsinki declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on Springer. com.

Disclaimer

The authors are solely responsible for the data and the content of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, or the printer/publishers are responsible for the results/findings and content of this article.

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Copyright information

© Indian Society of Gastroenterology 2019

Authors and Affiliations

  • Ayush Jain
    • 1
  • Bhupinder Singh Kalra
    • 1
  • Siddharth Srivastava
    • 2
  • Shalini Chawla
    • 1
    Email author
  1. 1.Department of PharmacologyMaulana Azad Medical CollegeNew DelhiIndia
  2. 2.Department of GastroenterologyGovind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew DelhiIndia

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