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Indian Journal of Gastroenterology

, Volume 37, Issue 3, pp 235–242 | Cite as

Helicobacter pylori is associated with increased risk of serrated colonic polyps: Analysis of serrated polyp risk factors

  • Anand Kumar
  • Mimi Kim
  • Dana J. Lukin
Original Article

Abstract

Background

Sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA) are recognized precursors of colorectal cancer, but their risk factors are not well established. We investigated the association between Helicobacter pylori infection (HPI) and the development of SSA and TSA.

Methods

Retrospective data were collected on patients aged ≥ 18 years that underwent colonoscopy with biopsy between 2006 and 2016. Based on histology, patients were classified into three groups: those with SSA and/or TSA, (serrated neoplasia group, SN); conventional adenomas only (CA); and with no polyps (NP). Gastric HPI status, demographic, and clinical risk factors were compared between groups using bivariate and multivariable analysis.

Results

HPI was significantly associated with increased risk of SN (SN vs. NP: OR 1.71 [95% CI 1.29–2.27]; SN vs. CA: 1.49 [1.14–1.96]). Additional factors associated with increased risk of SN included the following: age 50–75 years, compared to younger age (SN vs. NP: 2.83 [1.69–4.74]), female gender (SN vs. CA: 1.28 [0.99–1.64]), White race, compared to Blacks (SN vs. CA: 1.52 [1.07–2.15)], overweight and obese body mass index [SN vs. NP: p < 0.001) and current smoking status (SN vs. CA: 2.09 [1.55–2.82)]. Among SN, higher HPI prevalence was associated with dysplasia (p = 0.05) and proximal location (p = 0.01).

Conclusions

Our data suggest that gastric HPI is associated with increased risk of SN and CA, with a stronger association with SN as compared to CA. Age 50–75 years, female gender, White race, obesity, and smoking were also predictors of SN. A positive correlation of HPI with proximal and dysplastic SN suggests a possible role in serrated pathway carcinogenesis. Prospective studies with large patient population are needed to further investigate this association.

Keywords

Colorectal neoplasia Helicobacter pylori Serrated polyp Sessile serrated adenoma Traditional serrated adenoma 

Notes

Compliance with ethical standards

Conflict of interest

AK, MK, and DJL declare that they have no conflict of interest.

Ethics statement

The study was performed in a manner to conform with the Helsinki Declaration of 1975, as revised in 2000 and 2008concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on Springer.com. The study was approved by the Institutional Review Board at the Albert Einstein College of Medicine.

Supplementary material

12664_2018_855_MOESM1_ESM.docx (23 kb)
Supplementary Table 1 (DOCX 22 kb)

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Copyright information

© Indian Society of Gastroenterology 2018

Authors and Affiliations

  1. 1.Department of MedicineMontefiore Medical CenterNew YorkUSA
  2. 2.Department of Epidemiology and Population HealthAlbert Einstein College of MedicineNew YorkUSA
  3. 3.Division of GastroenterologyAlbert Einstein College of Medicine, Montefiore Medical CenterNew YorkUSA

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