Prevalence and factors associated with gastroesophageal reflux disease in southern India: A community-based study
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Background and Aim
Gastroesophageal reflux disease (GERD) is common worldwide with significant expenditure for health care. Community-based data on the prevalence of GERD in India remains scarce. This study was conducted to determine the prevalence of GERD and to identify potential associations.
A community-based survey of adults (aged ≥18 years) was done through population proportionate to size sampling in urban and rural areas of Vellore district, Tamil Nadu, India. GERD was defined as heartburn and regurgitation occurring at least twice per week. Associations between GERD and gender, age, anthropometric measures, and consumption of tobacco, alcohol, meat, and milk were evaluated. Odds ratios (OR) with 95% confidence intervals were derived from logistic regression models.
Of 6174 participants (3157 urban, 2599 male), 8.2% had GERD. The prevalence was higher in urban (11.1%) compared to rural areas (5.1%) (p < 0.001). Among patients with GERD, 34.3% used medications daily for symptom relief. On univariate analysis, GERD was associated with female gender, living in an urban area, age >30, BMI >25, and infrequent milk consumption. On multivariate analysis, female gender (OR 1.3; 95% CI 1.1–1.6), living in urban area (OR 2.3; 95% CI 1.9–2.8), age >30 years (OR 1.9; 95% CI 1.4–2.5), BMI ≥ 25 kg/m2 (OR 1.3; 95% CI 1.1–1.6), and infrequent milk intake (OR 1.6; 95% CI 1.3–1.9) were independently associated with GERD.
KeywordsGastroesophageal reflux disease Heartburn India Obesity Prevalence
Compliance with ethical standards
Conflict of interest
SDC, GG, KR, BR, SP, JM, LJ, and BSR declare that they have no conflict of interest.
The authors declare that the study was performed in a manner conforming to the Helsinki declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on Springer.com. The study was approved by the Institutional Review Board of the Christian Medical College, Vellore.
All participants provided written informed consent.
The authors are solely responsible for the data and the content of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, or the printer/publishers are responsible for the results/findings and content of this article.
- 1.Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006;101:1900–920; quiz 1943.Google Scholar
- 8.IND_India.pdf [Internet]. [cited 2014 Apr 13]. Available from: http://censusindia.gov.in/2011census/censusinfodashboard/stock/profiles/en/IND_India.pdf. Accessed 10 Jan 2019
- 11.Kumar N, Shekhar C, Kumar P, Kundu AS. Kuppuswamy’s socioeconomic status scale-updating for 2007. Indian J Pediatr. 2007;74:1131–2.Google Scholar
- 12.An evidence-based appraisal of reflux disease management--the Genval Workshop Report. Gut. 1999;44 Suppl 2:S1–16.Google Scholar
- 13.WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363:157–63.Google Scholar
- 26.Cossentino MJ, Wong RKH. Barrett’s esophagus and risk of esophageal adenocarcinoma. Semin Gastrointest Dis. 2003;14:128–35.Google Scholar
- 32.Sethi S, Richter JE. Diet and gastroesophageal reflux disease: role in pathogenesis and management. Curr Opin Gastroenterol. 2017;33:107–11.Google Scholar