Journal of Maxillofacial and Oral Surgery

, Volume 18, Issue 1, pp 131–138 | Cite as

To Evaluate the Efficacy and Effectiveness of N-butyl-2-cyanoacrylate glue (TRU SEAL) in Closure of Oral and Maxillofacial Laceration and Surgical Incisions

  • Praveen Kumar SinghEmail author
  • Saikrishna Degala
  • Sujeeth Shetty
  • Vijay Singh Rai
  • Asutosh Das
Original Article



Effective wound closure is critical for minimizing wound complications and preventing wound dehiscence. The various wound closure techniques include staples, traditional nylon and skin sutures, subcuticular sutures, and skin adhesives. Currently topical skin adhesives are frequently being used. It offers countless advantages: short application time, easy execution as well as possessing hemostatic character. N-butyl-2-cyanoacrylate is bacteriostatic and biodegradable and exhibits suitable tensile strength.

Materials and Methods

Under nasoendotracheal intubation, the reduction in fracture and plating was done. In 80% of the patients, subcutaneous sutures were placed. Skin closure was done with N-butyl-2-cyanoacrylate glue.


In this study, REEDA scale was used to assess healing. Redness, edema, and ecchymosis were seen in all 10 patients, which subsided by the second week postoperatively. None of the patients had discharge from surgical site on the first postoperative day but was noted in two patients the first week postoperatively. There was evidence of wound gaping in one patient on the first postoperative day and two patients at end of the first week postoperatively. Stony Brook Scar Evaluation was used to evaluate postoperative cosmesis. No significant cosmetic impairment was found in all patients at the end of the study.


The study reflects qualitative assessment of cyanoacrylates which is simple to use and proper application which resulted in uniform and everted closure of wound. It is cost-efficient as compared to other wound closure materials.


N-butyl-2-cyanoacrylate glue Tissue adhesive Surgical incisions Lacerations 


  1. 1.
    Barreno AC, Vergiu CC, Malatto JR, Ramos EA, Chessa JR (2013) Biocompatibilidad del cianoacrilato de butilo en suturas en piel en comparación con las suturas convencionales. Rev Odontol Mex 17(2):81–89Google Scholar
  2. 2.
    Taira BR, Singer AJ, Rooney J, Steinhauff NT, Zimmerman T (2010) An in vivo study of the wound-bursting strengths of octyl-cyanoacrylate, butyl-cyanoacrylate, and surgical tape in rats. J Emerg Med 38(4):546–551CrossRefGoogle Scholar
  3. 3.
    Habib A, Mehanna A, Medra A (2013) Cyanoacrylate: a handy tissue glue in maxillofacial surgery: our experience in alexandria, Egypt. J Maxillofac Oral Surg 12(3):243–247CrossRefGoogle Scholar
  4. 4.
    Idle MR, Monaghan AM, Lamin SM, Grant SWJ (2013) N-butyl 2-cyanoacrylate agent in a venous malformation of the mandible. Br J Oral Maxillofac Surg 51:565–567CrossRefGoogle Scholar
  5. 5.
    Al belasy FA, Amer MZ (2003) Hemostatic effect of N-butyl 2-cyanoacrylate glue in warfarin-treated patients undergoing oral surgery. J Oral Maxillofac Surg 61:1405–1409CrossRefGoogle Scholar
  6. 6.
    Robicsek F, Rielly JP, Marroum M-C (1994) The use of cyanoacrylate adhesive (krazy glue) in cardiac surgery. J Card Surg 9:353–356CrossRefGoogle Scholar
  7. 7.
    Noordzij JP, Foresman PA, Rodeheaver GT, Quinn JV, Edlich RF (1994) Tissue adhesive wound repair revisited. J Emerg Med 12(5):615–619CrossRefGoogle Scholar
  8. 8.
    Singer AJ, Zimmerman T, Rooney J, Cameau P, Rudomen G, Mcclain SA (2004) Comparison of wound bursting strengths and surface characteristics of FDA approved tissue adhesives for skin closure. J Adhes Sci Technol 18(1):19–27CrossRefGoogle Scholar
  9. 9.
    Bresnahan KS, Howell JM, Wizorek J (1995) Comparison of tensile strength of cyanoacrylate tissue adhesive closure of laceration versus suture closure. Ann Emerg Med 26:575–578CrossRefGoogle Scholar
  10. 10.
    Salata LA, Mariguela VC, Antunes AA, Grossi-Oliveira G, Almeida A, Taba M (2014) Short-term evaluation of grafts fixed with either n-butyl-2-cyanocrylate or screws. J Oral Maxillofac Surg 72:676–682CrossRefGoogle Scholar
  11. 11.
    Eaglstein WH, Sullivan TP, Giordano PA, Miskin BM (2002) A liquid adhesive bandage for the treatment of minor cuts and abrasions. Dermatol Surg 28:263–267Google Scholar
  12. 12.
    Kumar MS, Nata S, Shankar G, Reddy SH, Visalakshi D, Seshiah GV (2013) Comparison between silk sutures and cyanoacrylate adhesive in human mucosa—a clinical and histological study. J Int Oral Health 5(5):95–100Google Scholar
  13. 13.
    Greenhill GA, O’Regan B (2009) Incidence of hypertrophic and keloid scars after N-butyl 2-cyanoacrylate tissue adhesive had been used to close parotidectomy wounds: a prospective study of 100 consecutive patients. Br J Oral Maxillofac Surg 47:290–293CrossRefGoogle Scholar
  14. 14.
    Singer AJ, Quinn JV, Hollander JE (2008) The cyanoacrylate topical skin adhesives. Am J Emerg Med 26:490–496CrossRefGoogle Scholar
  15. 15.
    Leonard F, Kuliiarn RK, Nblson J, Rrandes G (1967) Tissue adhesives and hemostasis-inducing compounds: the alkyl cyanoacrylates. J Biomed Mater Iies 1:3–9CrossRefGoogle Scholar
  16. 16.
    Bass B, Bekciogulu B, Sanal KO, Gulbahar MY, Kbak YB (2012) Screw fixation is superior to n-butyl -2-cyanoacrylate in onlay grafting procedure: a histomorphologic study. Int J Oral Maxillofac Surg 41:537–543CrossRefGoogle Scholar
  17. 17.
    Leonard F, Hodge JW, Houston S, Ousterhout DK (1968) Α cyanoacrylate adhesive bond strengths with proteinaceous and nonproteinaceous substrates. J Biomed Mater Res 2:173–178CrossRefGoogle Scholar
  18. 18.
    Matsumoto T, Pani KC, Hardaway RM, Leonard F (1967) N-alkyl-a-cyanoacrylate monomers in surgery. Arch Surg 94:153–156CrossRefGoogle Scholar
  19. 19.
    Davis KP, Derlet RW (2013) Cyanoacrylate glues for wilderness and remote travel medical care. Wilderness Environ Med 24:67–74CrossRefGoogle Scholar
  20. 20.
    Toriumi DM, Raslan WF, Friedman M, Tardy ME (1990) Histotoxicity of cyanoacrylate tissue adhesives. Arch Otolaryngol Head Neck Surg 116:546–550CrossRefGoogle Scholar
  21. 21.
    Leggat PA, Smith DR, Kedjarune U (2007) Surgical applications of cyanoacrylate adhesives: a review of toxicity. ANZ J Surg 77:209–213CrossRefGoogle Scholar
  22. 22.
    Quinn J, Lowe L, Mertz M (2000) The effect of a new tissue-adhesive wound dressing on the healing of traumatic abrasions. Dermatology 201:343–346CrossRefGoogle Scholar
  23. 23.
    Osmond MH, Quinn JV, Sutcliffe T, Jarmuske M, Klassen TP (1999) A randomized, clinical trial comparing butylcyanoacrylate with octylcyanoacrylate in the management of selected pediatric facial lacerations. Acad Emerg Med 6:171–177CrossRefGoogle Scholar
  24. 24.
    Yaron M, Halperin M, Huffer W, Cairns C (1995) Efficacy of tissue glue for laceration repair in an animal model. Acad Emerg Med 2:259–263CrossRefGoogle Scholar

Copyright information

© The Association of Oral and Maxillofacial Surgeons of India 2018

Authors and Affiliations

  • Praveen Kumar Singh
    • 1
    Email author
  • Saikrishna Degala
    • 2
  • Sujeeth Shetty
    • 2
  • Vijay Singh Rai
    • 3
  • Asutosh Das
    • 3
  1. 1.Dr Praveen’s Maxillofacial & Implant CentreGorakhpurIndia
  2. 2.Department of Oral & Maxillofacial SurgeryJSS Dental College & HospitalMysuruIndia
  3. 3.MysuruIndia

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