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Journal of Maxillofacial and Oral Surgery

, Volume 18, Issue 2, pp 256–259 | Cite as

Comparative Study Between Oral Lorazepam and Diazepam as Sedation in Oral and Maxillofacial Surgery

  • Vikas SharmaEmail author
  • Amaninder Singh
  • Parul Sharma
  • Simranjeet Kaur
  • Akanksha Zutshi
Original Article
  • 53 Downloads

Abstract

Purpose

The aim of the study was to compare the efficacy of oral lorazepam as night sedation and premedication with diazepam.

Methods

A prospective, randomized, and double-blind study was done in 50 healthy patients in each drug group. The impacted third molar impaction was taken as the study model. Study was carried out after giving bioequivalent doses of respective drugs for either side. All the patients were assessed for quality of sleep, sedation, recall of visual stimuli, cooperation shown by patient and recovery postoperatively.

Results

The study concluded that lorazepam showed more advantages than diazepam as well as patient’s preference and satisfaction. However, postoperative recovery with lorazepam was longer than diazepam.

Keywords

Lorazepam Diazepam Sedation Premedication 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declares that they have no conflict of interests.

References

  1. 1.
    Ustun Y, Gunduz M, Erdogan O, Benlidayi EM (2006) Dexmedetomidine versus midazolam in outpatient third molar surgery. J Oral Maxillofac Surg 64(9):1353–1358CrossRefGoogle Scholar
  2. 2.
    Bennett J (2002) Discussion—remifentanil for use during conscious sedation in outpatient oral surgery. J Oral Maxillofac Surg 60:250CrossRefGoogle Scholar
  3. 3.
    Long DH, Eltringham RJ (1977) Lorazepam as night sedation and premedication: a comparison with dichloralphenazone and papaveretum. Anaesthesia 32:649–653CrossRefGoogle Scholar
  4. 4.
    Wilson J, Ellis FR (1973) Oral premedication with lorazepam: a comparison with heptabarbitone and diazepam. Br J Anaesth 45:738–744CrossRefGoogle Scholar
  5. 5.
    Magbagbeola JAO (1974) A comparison of lorazepam and diazepam as oral premedication for surgery under regional anaesthesia. Br J Anaesth 46:449–451CrossRefGoogle Scholar
  6. 6.
    Tornetta FJ (1965) Diazepam as pre anaesthetic medication—a double blind study. Anaesth Analg 44:449–452CrossRefGoogle Scholar
  7. 7.
    Haslett WHK, Dundee JW (1968) Study of drugs given before anaesthesia. XIV: two benzodiazepine derivative-chlordiazepoxide and diazepam. Br J Anaesth 40:250–258CrossRefGoogle Scholar
  8. 8.
    Dodson ME, Eastley RJ (1978) Comparative study of two long acting tranquillizers for oral premedication. Br J Anaesth 50:1059–1064CrossRefGoogle Scholar
  9. 9.
    Peterson LJ (1998) Principles of management of impacted teeth. In: Peterson LJ, Elllis E III, Hupp JR (eds) Contemporary oral and maxillofacial surgery. Mosby, St Louis, pp 215–248Google Scholar
  10. 10.
    Buysse DJ, Reynolds CF, Monk TH (1989) The pittsburg sleep quality index—a new instrument for psychiatric practice and research. Psychiatry Res 28(2):192–213CrossRefGoogle Scholar
  11. 11.
    Salmon FF, Mets B, James MF (1992) Intravenous sedation for ocular surgery under local anaesthesia. Br J Ophthalmol 76:598CrossRefGoogle Scholar
  12. 12.
    Ramsay MA, Savege TM (1974) Controlled sedation with alphaxalone–alphadolone. Br Med J 2:656–659CrossRefGoogle Scholar
  13. 13.
    Studd C, Eltringham RJ (1980) Lorazepam as night sedation and comparison premedication: a with diazepam. Anaesthesia 35(1):60–64CrossRefGoogle Scholar
  14. 14.
    Parworth LP, Frost DE, Zuniga JR (1998) Propofol and fentanyl compared with midazolam and fentanyl during third molar surgery. J Oral Maxillofac Surg 56:447CrossRefGoogle Scholar
  15. 15.
    Jensen AG, Moller JT, Lybecker H (1995) A random trial comparing recovery after midazolam alfentanil anaesthesia with and without reversal with flumazenil, and standardized neurolept anaesthesia for major gynecologic surgery. J Clinic Anesth 7:63CrossRefGoogle Scholar
  16. 16.
    Paymaster NJ (1973) Lorazepam in anaesthesia. Curr Med Res Opin 1:317–322CrossRefGoogle Scholar
  17. 17.
    Paymaster NJ (1973) Lorazepam as a preoperative medication. Anaesthesia 28:521–526CrossRefGoogle Scholar
  18. 18.
    Hawitt JM, Barr AM (1978) Premedication with lorazepam for bronchoscopy under general anaesthesia. Br J Anaesth 50:1149–1154CrossRefGoogle Scholar

Copyright information

© The Association of Oral and Maxillofacial Surgeons of India 2018

Authors and Affiliations

  1. 1.Oral and Maxillofacial SurgeryNational Dental CollegeDerabassiIndia
  2. 2.Conservative and EndodonticsNational Dental College and HospitalDerabassiIndia
  3. 3.PanchkulaIndia

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