Journal of Maxillofacial and Oral Surgery

, Volume 17, Issue 4, pp 576–581 | Cite as

Control of Postoperative Nausea and Vomiting in Oral and Maxillofacial Surgery Patients with Isopropyl Alcohol: A Prospective Randomized Clinical Trial

  • Dinesh Kumar VermaEmail author
  • Shallu Bansal
  • Parveen Sharma
  • Prabhu Sundararaman
Original Article



The present study was undertaken to evaluate the effectiveness of inhaled 70% isopropyl alcohol (IPA) in controlling postoperative nausea and vomiting (PONV) in oral and maxillofacial surgery patients undergoing surgery under general anesthesia (GA).

Materials and Methods

This was a prospective, randomized, case-controlled study done on 208 maxillofacial surgery patients operated under GA. Patient’s demographic data, APFEL score for risk of PONV, duration of surgery and duration of anesthesia were recorded preoperatively. The test arm of the study received inhalation of 70% IPA every half an hour in the postoperative period for 8 h along with ondansetron 4 mg i.v. every 6 h. The control arm received only ondansetron 4 mg i.v. every 6 h. Both the groups followed the same preoperative and postoperative instruction and drug protocol except the test drug. PONV was recorded using the simplified PONV intensity score and VAS. The scores were analyzed with Mann–Whitney test with < 0.05 considered significant.


The groups were similar with regard to age (p = 0.083), BMI (p = 0.1.00), sex (p = 0.379), type of surgery (p = 0.504), duration of anesthesia (p = 0.621), duration of surgery (p = 0.515) and APFEL score (p = 0.687). IPA inhalation group achieved significantly better simplified PONV scores and VAS scores at 4 h (p = 0.000), 6 h (p = 0.000) and 8 h (p = 0.000). PONV control at 2 h was similar to the control group.


Inhalation of 70% IPA every half an hour was associated with significant PONV control in maxillofacial surgery patients undergoing surgery under GA.


PONV Maxillofacial surgery Isopropyl alcohol Nausea and vomiting after surgery 


Compliance with ethical standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Institutional ethical clearance was obtained for the present study.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© The Association of Oral and Maxillofacial Surgeons of India 2018

Authors and Affiliations

  • Dinesh Kumar Verma
    • 1
    Email author
  • Shallu Bansal
    • 1
  • Parveen Sharma
    • 2
  • Prabhu Sundararaman
    • 3
  1. 1.Department of Oral and Maxillofacial SurgerySurendera Dental College and Research InstituteSri GanganagarIndia
  2. 2.Director Academic and ResearchTantia UniversitySri GanganagarIndia
  3. 3.Department of Oral and Maxillofacial SurgeryPeoples Dental AcademyBhopalIndia

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