Comparison of turbulent flow measurement schemes for 4D flow MRI
- 63 Downloads
Recently, time-resolved 3D phase contrast magnetic resonance imaging, which is also called 4D flow MRI or 4D PC-MRI, has been widely utilized to investigate spatial and temporal variations in the hemodynamic characteristics of blood flows. The conventional 4D flow MRI only provides the ensemble-averaged mean flow information but misses flow fluctuation because of turbulence. There have been some new manners for turbulence quantification of the blood flow using 4D flow MRI to acquire the fluctuation intensity of the turbulent flow. Although the previous studies showed that a minimum of six flow encoding is needed to perfectly describe six independent components of the 3 × 3 symmetric Reynolds stress tensor, the optimum flow encoding scheme for turbulence has not been clearly revealed. In this study, we compared and evaluated the uncertainty of mean velocity and Reynolds stress tensor in 4D flow MRI with various flow encoding schemes. The results showed that six- to fifteen-direction measurements could result 29–51% less noise in the velocity field and 34–57% less noise in the TKE field. In addition, higher number of flow encoding had less noise in Reynolds stress estimation.
Keywords4D flow MRI PC-MRI Phase contrast MRI Hemodynamics Blood flow
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2018R1D1A1A02043249). This study was supported by 2018 Research Grant (PoINT) from Kangwon National University.
- Dyverfeldt P, Hope MD, Tseng EE, Saloner D (2013) Magnetic resonance measurement of turbulent kinetic energy for the estimation of irreversible pressure loss in aortic stenosis. JACC: Cardiovascular Imaging 6:64–71Google Scholar
- Ku DN, Giddens DP, Zarins CK, Glagov S (1985) Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress. Arterioscler Thromb Vasc Biol 5:293–302Google Scholar
- Markl M, Wallis W, Strecker C, Gladstone BP, Vach W, Harloff A (2012b) Analysis of pulse wave velocity in the thoracic aorta by flow-sensitive four-dimensional MRI: reproducibility and correlation with characteristics in patients with aortic atherosclerosis. J Magn Reson Imaging 35:1162–1168CrossRefGoogle Scholar
- Uretsky S, Gillam LD (2013) “ Nature vs. Nurture” in Bicuspid aortic valve aortopathy: more evidence that altered hemodynamics may play a role. Circulation. https://doi.org/10.1161/circulationaha.1113.007282 Google Scholar