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Neurotoxicity Research

, Volume 35, Issue 4, pp 955–968 | Cite as

Asiatic Acid Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress and Apoptosis Via AKT/GSK-3β Signaling Pathway in Wistar Rats

  • Mashoque Ahmad Rather
  • Arokiasamy Justin-ThenmozhiEmail author
  • Thamilarasan Manivasagam
  • Chidambaram Saravanababu
  • Gilles J. Guillemin
  • Musthafa Mohamed Essa
Original Article

Abstract

Asiatic acid (AA), a triterpenoid present in Centella asiatica, possesses the ability to cross blood brain barrier and received considerable attention for its neuroprotective role. We have reported the benefit of AA against aluminum chloride (AlCl3)-induced amyloid pathology, enhanced acetylcholine esterase (AChE) activity, and inflammation in Alzheimer’s disease (AD) like model rats. Based on that, to find the exact mechanism of action of AA, the present study was designed to evaluate the oxidative stress, tau pathology, apoptosis, and Akt/GSK3β signaling pathway on AlCl3-induced neurotoxicity in Wistar rats. AD-like pathology was induced by oral administration of AlCl3 (100 mg/kg b.w.) for 6 weeks, which demonstrated a significant reduction in spatial memory performance, anxiety, and motor dysfunction and diminished the expression of cyclin-dependent kinase 5 (CDK 5-enzyme implicated in the phosphorylation of tau proteins), pTau, oxidative stress, and apoptosis, whereas oral ingestion of AA (75 mg/kg b.w.) for 7 weeks attenuated the above-said indices, which could be by activating Akt/GSK3β pathway. Current results suggested that AA could be able to modulate various pathological features of AD and could hold promise in AD treatment.

Keywords

Aluminum chloride Asiatic acid Oxidative stress Tau pathology Apoptosis 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Mashoque Ahmad Rather
    • 1
  • Arokiasamy Justin-Thenmozhi
    • 1
    Email author
  • Thamilarasan Manivasagam
    • 1
  • Chidambaram Saravanababu
    • 2
  • Gilles J. Guillemin
    • 3
  • Musthafa Mohamed Essa
    • 4
    • 5
    • 6
  1. 1.Department of Biochemistry and BiotechnologyAnnamalai UniversityAnnamalai NagarIndia
  2. 2.Department of Pharmacology, JSS College of PharmacyJSS Academy of Higher Education and Research (JSSAHER)MysuruIndia
  3. 3.Neuroinflammation group, Faculty of Medicine and Health Sciences, Deb Bailey MND Research LaboratoryMacquarie UniversitySydneyAustralia
  4. 4.Department of Food Science and Nutrition, CAMSSultan Qaboos UniversityMuscatOman
  5. 5.Ageing and Dementia Research GroupSultan Qaboos UniversityMuscatOman
  6. 6.Food and Brain Research FoundationChennaiIndia

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