Elevated Hs-CRP Levels Are Associated with Higher Risk of Intracranial Arterial Stenosis
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Correlation between the level of high-sensitivity C-reactive protein (hs-CRP) and the incidence of intracranial arterial stenosis (ICAS) is unclear. We aim to investigate the relationship between hs-CRP levels and ICAS. A total of 1458 patients aged ≥ 40 years were enrolled in this study. All the participants had a magnetic resonance angiography (MRA) examination for the evaluation of ICAS. Participants were classified into four groups according to stroke and ICAS. Multivariable logistic regression models were used to assess the relationship of hs-CRP levels and ICAS status. A total of 432 (29.63%) subjects had ICAS. The levels of hs-CRP in stroke group were significantly higher than those in non-stroke group (p < 0.001). Patients with ICAS tend to have higher hs-CRP levels (p < 0.001). In multivariate analysis, the fourth hs-CRP quartile had the strongest association with ICAS in both stroke group and non-stroke group (OR 2.512, 95% CI 1.651–3.853, p < 0.001 for stroke group, and OR 2.534, 95% CI 1.435–4.595, p = 0.002 for non-stroke group) among the four quartiles of hs-CRP levels. Our study suggests that elevated serum hs-CRP levels are associated with higher risk of ICAS, in both stroke patients and non-stroke participants.
KeywordsHigh-sensitivity C-reactive protein Intracranial arterial stenosis Stroke Atherosclerosis Inflammation
anterior cerebral artery
acute ischemic stroke
high-sensitivity C-reactive protein
internal carotid artery
intracranial arterial stenosis
middle cerebral artery
magnetic resonance angiography
non-acute ischemic stroke
posterior cerebral artery
We thank all the study participants for their assistants and supports.
JTY, LT, and QD conceptualized the study, analyzed and interpreted the data, and drafted and revised the manuscript. BJS, YD, and CCT analyzed and interpreted the data, drafted and revised the manuscript, did the statistical analysis, and prepared all the figures. XHH, WX, MC, and FRS did the interpretation of the data and revision of the manuscript. All authors contributed to the writing and revisions of the paper and approved the final version.
This study was supported by grants from the Taishan Scholars Program of Shandong Province (ts201511109 and tsqn20161079) and Qingdao Key Health Discipline Development Fund; Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX01) and ZHANGJIANG LAB; Tianqiao and Chrissy Chen Institute; and the State Key Laboratory of Neurobiology and Frontiers Center for Brain Science of Ministry of Education, Fudan University.
Compliance with Ethical Standards
Written informed consent form was obtained from all participants or their legal representatives. This study was approved by the Institutional Ethics Committees of Qingdao Municipal Hospital
Conflict of Interest
The authors declare that they have no conflicts of interest.
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