Neurotoxicity Research

, Volume 35, Issue 1, pp 63–70 | Cite as

Serum Uric Acid Is Highly Associated with Epilepsy Secondary to Cerebral Infarction

  • Dongxing Wang
  • Bo Hu
  • Yongping Dai
  • Jing Sun
  • Zhaoxia Liu
  • Yu FengEmail author
  • Feng ChengEmail author
  • Xia ZhangEmail author


In this study, we examined the association between serum uric acid levels and epilepsy secondary to cerebral infarction. Clinical data including age, gender, epileptic seizure type, imaging, and serum uric acid levels before and after seizures in patients with cerebral infarction that were collected and analyzed. One hundred patients with cerebral infarction but without epilepsy, 147 patients with epilepsy secondary to cerebral infarction, and 55 patients with status epilepticus secondary to cerebral infarction were recruited. Interestingly, epilepsy secondary to cerebral infarction was associated with both reduced uric acid (adjusted OR 2.09; 95% CI 1.07–4.08) and increased uric acid (adjusted OR 4.05; 95% CI 1.99–8.25); however, status epilepsy secondary to cerebral infarction was only associated with increased uric acid (adjusted OR 2.60; 95% CI 1.05–6.45). A U-shaped association between uric acid levels and seizures was observed by using a multivariable logistic regression model with restricted cubic spline. Serum uric acid levels are associated with both epilepsy secondary to cerebral infarction and status epilepticus secondary to cerebral infarction in patients with cerebral infarction. The appropriate intervention of serum uric acid level might be a therapeutic strategy to reduce epileptic seizures or inhibit the development of status epilepticus.


Uric acid Epilepsy Cerebral infarction Stroke Risk factor 


Funding Information

This study was supported by the grant from Suzhou science and technology development program (SYSD2011087 to ZX).

Compliance with Ethical Standards

The research was approved by the local Ethics Committee of Soochow University. We confirm that we have read the journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurologyThe Second Affiliated Hospital of Soochow UniversitySuzhouChina
  2. 2.Department of Internal MedicineZhou Shi People’s HospitalSuzhouChina
  3. 3.Department of EndocrinologyThe Second Affiliated Hospital of Soochow UniversitySuzhouChina

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