Journal of Parasitic Diseases

, Volume 43, Issue 4, pp 601–606 | Cite as

Demographic and clinical profile of microspodial keratitis in North India: an underreported entity

  • Sumeeta KhuranaEmail author
  • Sonu Kumari Agrawal
  • Kirti Megha
  • Sujata Dwivedi
  • Neha Jain
  • Amit Gupta
Original Article


Ocular microsporidiosis was first described in immunocompromised subjects but recent reports have also shown cases in immunocompetent hosts. The database of existing clinical studies is very limited. The aim of present study was to analyse demographic profile, clinical features, microbiological profile, treatment and outcome of ocular microsporidiosis in northern India. The present study was carried out in the Department of Medical Parasitology, Advanced Eye Center, Postgraduate Institute of Medical Education and Research, and Bharat Vikas Parishad Charitable trust, Chandigarh. A total of 250 patients during year 2013–17 and suspected of microsporidial keratitis (either clinically or after exclusion of bacterial, viral or fungal agents). Corneal scraping were taken and subjected for various staining methods and PCR. 8 patients of microsporidial keratitis were confirmed, based on positivity by at least any two of the above mentioned techniques. None of the patients had history of contact lens wear or exposure to swimming pool. All these patients were systemically healthy and HIV serology was negative except one had history of diabetes mellitus. This study is a reminder to clinicians that when multifocal diffuse epithelial keratitis and culture-negative keratoconjunctivitis not responding to medical therapy, regardless of immune status are found in patients with symptoms suggesting an infectious keratitis, microsporidial keratoconjunctivitis should be included in the differential diagnosis.


Microsporidia Keratoconjunctivitis Ocular microsporidiosis 


Authors’ contribution

SK guided the study and checked the paper, SKA wrote the paper and also performed the experiment, KM did the staining and pcr, NJ collected the sample, SD and AG helped in providing the samples.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interest.


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Copyright information

© Indian Society for Parasitology 2019

Authors and Affiliations

  • Sumeeta Khurana
    • 1
    Email author
  • Sonu Kumari Agrawal
    • 1
  • Kirti Megha
    • 1
  • Sujata Dwivedi
    • 2
  • Neha Jain
    • 1
  • Amit Gupta
    • 3
  1. 1.Department of Medical ParasitologyPGIMERChandigarhIndia
  2. 2.Bharat Vikas Charitable TrustChandigarhIndia
  3. 3.Advanced Eye CenterPGIMERChandigarhIndia

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