, Volume 11, Issue 2, pp 703–711 | Cite as

Progesterone Release from PDMS-Modified Silica Xerogels Containing Ag Nanoparticles

  • Elmira Banaee Mofakham
  • Azadeh GhaeeEmail author
  • Arezou Mashak
  • Mehdi Razzaghi-Abyaneh
Original Paper


The objective of this study is to investigate the effects of adding PDMS and Ag nanoparticles on chemical and physical properties of silica xerogels as well as release behavior of progesterone. Pure silica, silica-PDMS, silica-Ag nanoparticles, and silica-PDMS-Ag nanoparticles xerogels were prepared using a sol-gel method as progesterone delivery systems. Tetraethoxysilane (TEOS) was used as silica matrix precursor, polydimethylsiloxane (PDMS) and Ag nanoparticles were used as additives. In vitro studies showed that progesterone had biphasic release profile and diffusion was the dominant releasing mechanism. Also addition of PDMS and Ag nanoparticles controlled the release rate of the drug. According to in vitro experiments, due to existing Ag nanoparticles in Silica-PDMS-Ag nanoparticles xerogels, these xerogels presented antimicrobial behavior against Escherichia coli as gram-negative, Staphylococcus aureus as gram-positive standard bacteria and Candida albicans. This study showed that these xerogels could be used for local delivery of progesterone besides inhibiting infections by silver nanoparticles.


Silica PDMS Progesterone Sol-gel Ag nanoparticles 


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This work was supported by the Faculty of New Sciences and Technologies, University of Tehran, Iran (No. 28771/06/02). Also, the participation of R. Tolouei (Department of Mycology, Pasteur Institute of Iran, P.O. Box: 131694-3551, Tehran, Iran) in the experimentation is gratefully acknowledged.


  1. 1.
    Czarnobaj K, Czarnobaj J (2008) Sol-gel processed porous silica carriers for the controlled release of Diclofenac Diethylamine. Biomed Mater Res Part B Appl Biomater 87:114–120CrossRefGoogle Scholar
  2. 2.
    Gaetano FDE, Ambrosio L, Raucci MG, Marotta A, Catauro M (2005) Sol-gel processing of drug delivery materials and release kinetics. Mater Sci Mater Med 16:261–265CrossRefGoogle Scholar
  3. 3.
    Radin S, Falaize S, Lee MH, Duchyne P (2002) In vitro bioactivity and degradation behavior of silica xerogels intended as controlled release materials. Biomaterals 23:3113–3122CrossRefGoogle Scholar
  4. 4.
    Czarnobaj K (2011) Sol–gel-processed silica/polydimethylsiloxane/calcium xerogels as polymeric matrices for Metronidazole delivery system. Poly Bull 66:223–237CrossRefGoogle Scholar
  5. 5.
    Kortesuo P, Ahola M, Kangas M, Yli-Urpo A, Kiesvaara J, Marvola M (2001) In vitro release of dexmedetomidine from silica xerogel monoliths: effect of sol-gel synthesis parameters. Int J Pharm 221:107–114CrossRefGoogle Scholar
  6. 6.
    Fidalgo A, Ilharco M (2004) Correlation between physical properties and structure of silica xerogels. Non Cryst Solids 347:128–137CrossRefGoogle Scholar
  7. 7.
    Ahola M, Kortesuo P, Kangasniemi I, Kiesvaara J, Yli-Urpo A (2000) Silica xerogel carrier material for controlled release oftoremifene citrate. Int J Pharm 195:219–227CrossRefGoogle Scholar
  8. 8.
    Kortesuo P, Ahola M, Karlsson S, Kangasniemi I, Yli-Urpo A, Kiesvaara J (2000) Silica xerogel as an implantable carrier for controlled drug delivery-evaluation of drug distribution and tissue effects after implantation. Biomaterials 21:193–198CrossRefGoogle Scholar
  9. 9.
    Kortesuo P, Ahola M, Kangas M, Leino T, Laakso S, Vuorilehto L, Yli-Urpo A, Kiesvaara J, Marvola M (2001) Alkyl-substituted silica gel as a carrier in the controlled release of dexmedetomidine. Control Release 76:227–238CrossRefGoogle Scholar
  10. 10.
    Domingues ZR, Corts ME, Goms TA, Diniz HF, Freitas CS, Gomes JB, Faria AMC (2004) Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with b-cyclodextrin. Biomaterials 25:327–333CrossRefGoogle Scholar
  11. 11.
    Bottcher H, Slowik P, Sub W (1998) Sol-gel carrier systems for controlled drug delivery. Sol-Gel SciTechnol 13:277–281CrossRefGoogle Scholar
  12. 12.
    Smirnova I, Suttiruengwong S, Arlt W (2004) Feasibility study of hydrophilic and hydrophobic silica aerogels as drug delivery systems. Non Cryst Solids 350:54–60CrossRefGoogle Scholar
  13. 13.
    Sieminska L, Zerda TW (1996) Diffusion of steroids from sol-gel glass. Phys Chem 100:4591–4597CrossRefGoogle Scholar
  14. 14.
    Sieminska L, Ferguson M, Zerda TW, Couch E (1997) Diffusion of steroids in porous sol-gel glass: application in slow drug delivery. Sol-Gel SciTechnol 8:1105–1109Google Scholar
  15. 15.
    Rivero PJ, Urrutia A, Goicoechea J, Zamarrno CR, Arregui FJ, Matias IR (2011) An antibacterial coating based on a polymer/sol-gel hybrid matrix loaded with silver nanoparticles. Nanoscale Res Lett 6:1–7CrossRefGoogle Scholar
  16. 16.
    Tsuru K, Aburatani Y, Yabuta T, Hayakawa S, Ohtsuki C, Osaka A (2000) Synthesis and in vitro behavior of organically modified silicate containing Ca Ions. Sol-Gel SciTechnol 21:89–96CrossRefGoogle Scholar
  17. 17.
    Latha MS, Lai AV, Kumary TV, Sreekumar R, Jayakrishnan A (2000) Progesterone release from glutaraldehyde cross-linked casein microspheres: in vitro studies and in vivo response in rabbits. Contraception 61:329–332CrossRefGoogle Scholar
  18. 18.
    Jameela SR, Kumary TV, Lai AV, Jayakrishnan A (1998) Progesterone-loaded chitosan microspheres: a long acting biodegradable controlled delivery system. Control Release 52:17–24CrossRefGoogle Scholar
  19. 19.
    Kalkwarf DR, Sikov MR, Smith L, Gordon R (1972) Release of progesterone from polyethylene devices in vitro and in experimental animals. Contraception 6:423–431CrossRefGoogle Scholar
  20. 20.
    Mashak A, Taghizadeh SM (2006) In vitro progesterone release from g-irradiated cross-linked polydimethylsiloxane. Radiat Phys Chem 75:229–235CrossRefGoogle Scholar
  21. 21.
    Jensen JT (2013) Vaginal ring delivery of selective progesterone receptor modulators for contraception. Contraception 87:314–318CrossRefGoogle Scholar
  22. 22.
    Jeon HJ, Yi SC, Oh SG (2003) Preparation and antibacterial effects of Ag–SiO2 thin films by sol–gel method. Biomaterials 24:4921–4928CrossRefGoogle Scholar
  23. 23.
    Quang DV, Sarawade PB, Hilonga A, Kim JK, Chai YG, Kim SH, Ryu JY, Kim HT (2011) Preparation of silver nanoparticle containing silica micro beads and investigation of their antibacterial activity. Appl Surf Sci 257:6963–6970CrossRefGoogle Scholar
  24. 24.
    Quang DV, Sarawade PB, Hilonga A, Kim JK, Chai YG, Kim SH, Ryu JY, Kim HT (2011) Preparation of amino functionalized silica micro beads by dry method for supporting silver nanoparticles with antibacterial properties. Colloids Surf A Physicochem Eng Asp 389:118–126CrossRefGoogle Scholar
  25. 25.
    Quang DV, Sarawade PB, Hilonga A, Park SD, Kim JK (2011) Facile route for preparation of silver nanoparticle-coated precipitated silica. Appl Surf Sci 257:4250–4256CrossRefGoogle Scholar
  26. 26.
    Stobie N, Duffy B, Mccormack DE, Colreavy J, Hidalgo M, Mchale P, Hindr PM (2008) Prevention of Staphylococcus epidermidis biofilm formation using a low-temperature processed silver-doped phenyltriethoxysilane sol–gel coating. Biomaterials 29:963–96CrossRefGoogle Scholar
  27. 27.
    Egger S, Lehmann RP, Height MJ, Loessner MJ, Schuppler M (2009) Antibacterial properties of a novel silver silica nanocomposite material. Appl Environ Microbiol 75:2973–2976CrossRefGoogle Scholar
  28. 28.
    Yang H, Liu Y, Shen Q, Chen L, You W, Wang X, Sheng J (2012) Mesoporous silica microcapsule-supported Ag nanoparticles fabricated via nano-assembly and its antibacterial properties. Mater Chem 22:24132–24138CrossRefGoogle Scholar
  29. 29.
    Lopez-Goerne TM, Lopez-Garcia MG, Rodriguez-Grada G, Ortiz Perez I, Gomez Lopez E, Alvarez Lemus MA (2013) Obtaining of Sol-Gel ketorolac-silica nanoparticles: characterization and drug release kinetics. Nanomater 2013:1–9CrossRefGoogle Scholar
  30. 30.
    Rubio F, Rubio J, Oteo JL (2013) A FT-IR study of the hydrolysis of tetraethyl orthosilicate (TEOS). Spectrosc Lett 31:199–219CrossRefGoogle Scholar
  31. 31.
    Ro JC, Chung IJ (1991) Structures and properties of silica gels prepared by the sol—gel method. Non Cryst Solids 130:8–17CrossRefGoogle Scholar
  32. 32.
    Tellez L, Rubio J, Rubio F, Morales E, Oteo JL (2006) FT-IR study of the hydrolysis and polymerization of tetraethyl orthosilicate and polydimethyl siloxane in the presence of tetrabutyl orthotitanate. Spectrosc Lett 37:11–31CrossRefGoogle Scholar
  33. 33.
    Chakrabarti K, Whang CM (2001) Structural and physical properties of Ag doped poly(dimethylsiloxane) modified silica xerogels. Appl Phys 90:6493–6499CrossRefGoogle Scholar
  34. 34.
    Lindsay EN (1989) Vaginal infections. Can Fam Physician 35:1323–1326Google Scholar
  35. 35.
    Eiff CV, Jansen B, Kohnen W, Becker K (2005) Infections associated with medical devices. Drugs 65:179–214CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Life Science Engineering, Faculty of New Sciences & TechnologiesUniversity of TehranTehranIran
  2. 2.Department of Novel Drug Delivery SystemsIran Polymer and Petrochemical InstituteTehranIran
  3. 3.Department of MycologyPasteur Institute of IranTehranIran

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