Intracuff local anesthetic to reduce postoperative sore throat: a randomized clinical trial
- 17 Downloads
To the Editor,
Postoperative sore throat (POST) following tracheal intubation is reported in 30–70% of patients,1 and is ranked by patients as the sixth most important postoperative complication.2 Instillation of a short-acting local anesthetic, lidocaine, in the endotracheal tube (ETT) cuff reduced postoperative sore throat at one and 24 hr.3 We hypothesized intracuff ropivacaine, a longer acting local anesthetic with a relatively safe cardiovascular toxicity profile, would reduce the severity and incidence of POST on postoperative day one (POD 1).
Following Research Ethics Board approval (Bio18-09 2018, March) and protocol registration (NCT03563963), we conducted a randomized blinded multisite clinical trial comparing POST between three groups: 1) ETT cuff inflated with ropivacaine 0.5%, 2) ETT cuff inflated with lidocaine 2%, and 3) ETT cuff inflated with air (standard care). Informed consent was obtained from those participants aged >18 yr, with American Society of...
The authors gratefully acknowledge the many participants involved in this study and the Saskatchewan Health Authority for their support of this research.
College of Medicine University of Saskatchewan.
This submission was handled by Dr. Gregory L. Bryson, Deputy Editor-in-Chief, Canadian Journal of Anesthesia.
Data availability statement
Raw data available at: firstname.lastname@example.org.
Full protocol available at email@example.com.
www.clinicaltrials.gov, NCT03563963; registered 20 June, 2018.
- 1.Tanaka Y, Nakayama T, Nishimori M, Tsujimura Y, Kawaguchi M, Sato Y. Lidocaine for preventing postoperative sore throat. Cochrane Database Syst Rev 2015; 7: CD004081.Google Scholar
- 3.Lam F, Lin YC, Tsai HC, Chen TL, Tam KW, Chen CY. Effect of intracuff lidocaine on postoperative sore throat and the emergence phenomenon: a systematic review and meta-analysis of randomized controlled trials. PLoS One 2015; DOI: https://doi.org/10.1371/journal.pone.0136184.CrossRefPubMedPubMedCentralGoogle Scholar