Intracuff local anesthetic to reduce postoperative sore throat: a randomized clinical trial

  • Megan McLachlanEmail author
  • Jonathan Gamble
  • Jennifer M. O’Brien
  • William P. McKay
  • Jagmeet S. Bajwa

To the Editor,

Postoperative sore throat (POST) following tracheal intubation is reported in 30–70% of patients,1 and is ranked by patients as the sixth most important postoperative complication.2 Instillation of a short-acting local anesthetic, lidocaine, in the endotracheal tube (ETT) cuff reduced postoperative sore throat at one and 24 hr.3 We hypothesized intracuff ropivacaine, a longer acting local anesthetic with a relatively safe cardiovascular toxicity profile, would reduce the severity and incidence of POST on postoperative day one (POD 1).

Following Research Ethics Board approval (Bio18-09 2018, March) and protocol registration (NCT03563963), we conducted a randomized blinded multisite clinical trial comparing POST between three groups: 1) ETT cuff inflated with ropivacaine 0.5%, 2) ETT cuff inflated with lidocaine 2%, and 3) ETT cuff inflated with air (standard care). Informed consent was obtained from those participants aged >18 yr, with American Society of...



The authors gratefully acknowledge the many participants involved in this study and the Saskatchewan Health Authority for their support of this research.

Competing interest



College of Medicine University of Saskatchewan.

Editorial responsibility

This submission was handled by Dr. Gregory L. Bryson, Deputy Editor-in-Chief, Canadian Journal of Anesthesia.

Data availability statement

Raw data available at:

Reproducible science

Full protocol available at

Trial registration, NCT03563963; registered 20 June, 2018.


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Copyright information

© Canadian Anesthesiologists' Society 2019

Authors and Affiliations

  • Megan McLachlan
    • 1
    Email author
  • Jonathan Gamble
    • 1
  • Jennifer M. O’Brien
    • 1
  • William P. McKay
    • 1
  • Jagmeet S. Bajwa
    • 1
  1. 1.Department of Anesthesiology, Perioperative Medicine and Pain ManagementUniversity of SaskatchewanSaskatoonCanada

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