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Associations of TNF-Α −308 G>A and TNF-Β 252 A>G with Physical Function and BNP—Rugao Longevity and Ageing Study

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To explore the associations of TNF-α −308 G>A (rs1800629) and TNF-β 252 A>G (rs909253) with physical function and plasma B-type natriuretic peptide (BNP).


Data of 1747 community-dwelling elders from the ageing arm of the Rugao Longevity and Ageing Study was used. Physical function was measured by handgrip strength, Timed Up and Go (TUG) test and 5-meter walking test (5MWT).


AA genotype of the TNF-α −308 G>A was associated with higher mean time of TUG test and 5MWT (multivariable adjusted β=5.75 and 5.70, respectively, p<0.05), compared with GG genotype. For the TNF-β 252 A>G polymorphism, GG genotype was associated with higher mean time of TUG test and 5MWT (multivariable adjusted β=1.55 and 0.83, respectively, p<0.05) and lower handgrip strength (multivariable adjusted β=−0.69, p<0.05), compared with AA genotype. Further, GG was associated with greater odds of low handgrip strength (OR=1.47, 95% CI=1.06–2.04), low speed of TUG test (OR=1.87, 95% CI=1.20–2.01) and elevated BNP (OR=1.30, 95% CI=1.08–1.84). GG also interacted with elevated BNP to be associated with greater odds of low handgrip strength and 5MWT.


TNF-β 252 A>G was associated with physical function measurements, plasma BNP level, and odds of elevated BNP in an elderly population. TNF-β 252 A>G also interacted with elevated BNP to be associated with greater odds of physical function measurements.

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We acknowledge all participants involved in the present study.


This work was financially supported by grants from the National Key R&D Program of China (2018YFC2000400, 2018YFC2002000) and the National Natural Science Foundation of China (81670465).

Author information

Correspondence to Li Jin or Xiao-Feng Wang.

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The Human Ethics Committee of the School of Life Sciences, Fudan University, Shanghai, People’s Republic of China, approved the present study. Written informed consent was obtained from all participants prior to the study.

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The authors declare that they have no conflict of interest.

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Yao, S., Zhu, Y.S., Shi, G.P. et al. Associations of TNF-Α −308 G>A and TNF-Β 252 A>G with Physical Function and BNP—Rugao Longevity and Ageing Study. J Nutr Health Aging 24, 358–363 (2020). https://doi.org/10.1007/s12603-020-1336-1

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Key words

  • Physical function
  • plasma BNP
  • TNF-α −308 G>A polymorphism
  • TNF-β 252 A>G polymorphism
  • population study